Home / TRAIL R2/TNFRSF10B / Human TRAIL R2/TNFRSF10B PE-conjugated Antibody

Human TRAIL R2/TNFRSF10B PE-conjugated Antibody

Catalog #: FAB6311P
41 Citations Datasheet
Catalog # Availability Size / Price Qty
FAB6311P-100
FAB6311P-025
MDA‑MB‑231 Human Cell Line by Flow Cytometry.
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Citations (41)
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Human TRAIL R2/TNFRSF10B PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human TRAIL R2 in direct ELISAs and Western blots. In direct ELISAs, does not cross-react with recombinant human (rh) TRAIL R1, rhTRAIL R3, rhTRAIL R4, or recombinant mouse TRAIL R2.
Source
Monoclonal Mouse IgG2B Clone # 71908
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TRAIL R2/TNFRSF10B
Ile56-Glu182
Accession # O14763
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry MDA‑MB‑231 Human Cell Line by Flow Cytometry. View Larger

MDA‑MB‑231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human TRAIL R2/TNFRSF10B PE-conjugated Monoclonal Antibody (Catalog # FAB6311P, filled histogram) or isotype control antibody (Catalog # IC0041P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TRAIL R2/TNFRSF10B

Human TRAIL R2, also known as DR5 and TRICK 2, is a type 1, TNF R family, transmembrane protein which is a receptor for TRAIL (APO2 Ligand). In the new TNF superfamily nomenclature, TRAIL R2 is referred to as TNFRSF10B. TRAIL R2 cDNA encodes a 440 amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. Among TNF receptor family proteins, TRAIL R2 is most closely related to TRAIL R1/DR4, sharing 55% amino acid sequence identity. Binding of trimeric TRAIL to TRAIL R2 induces apoptosis. The induction of apoptosis likely requires oligomerization of the receptor. The human TRAIL R2/Fc chimera neutralizes the ability of TRAIL to induce apoptosis. Besides TRAIL R2, an additional TRAIL R1/DR4, which tranduces apoptosis signaling, and two TRAIL decoy receptors, which antagonize TRAIL-induced apoptosis, have been reported.

Long Name
TRAIL Receptor 2
Entrez Gene IDs
8795 (Human); 21933 (Mouse)
Alternate Names
CD262 antigen; CD262; death domain containing receptor for TRAIL/Apo-2L; Death receptor 5; DR5; DR5TRICK2B; Fas-like protein; KILLER/DR5; KILLERapoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; TNFRSF10B; TRAIL R2; TRAIL receptor 2; TRAILR2; TRAIL-R2apoptosis inducing receptor TRAIL-R2; TRAILR2cytotoxic TRAIL receptor-2; TRICK2; TRICK2A; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9

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Citations for Human TRAIL R2/TNFRSF10B PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

41 Citations: Showing 1 - 10
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  1. Accumulation of autophagosomes in breast cancer cells induces TRAIL resistance through downregulation of surface expression of death receptors 4 and 5.
    Authors: Di X, Zhang G, Zhang Y et al.
    Oncotarget
  2. H-Ras regulation of TRAIL death receptor mediated apoptosis.
    Authors: Chen Jun-Jie, Bozza William P, Di Xu et al.
    Oncotarget.
  3. Cytokeratin 8/18 protects breast cancer cell lines from TRAIL-induced apoptosis
    Authors: Bozza WP, Zhang Y, Zhang B.
    Oncotarget
  4. Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP
    Authors: Christian Holmgren, Ellen Sunström Thörnberg, Victoria Granqvist, Christer Larsson
    Current Issues in Molecular Biology
  5. CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity
    Authors: D Bernareggi, Q Xie, BC Prager, J Yun, LS Cruz, TV Pham, W Kim, X Lee, M Coffey, C Zalfa, P Azmoon, H Zhu, P Tamayo, JN Rich, DS Kaufman
    Nature Communications, 2022-04-07;13(1):1899.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3
    Authors: D Raman, P Tay, JL Hirpara, D Liu, S Pervaiz
    Redox Biology, 2021-11-20;48(0):102193.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. FKBP51 Affects TNF-Related Apoptosis Inducing Ligand Response in Melanoma
    Authors: Tufano M, Cesaro E, Martinelli R et al.
    Frontiers in Cell and Developmental Biology
  8. Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis
    Authors: Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu
    Frontiers in Pharmacology
  9. Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody
    Authors: S Martini, M Figini, A Croce, B Frigerio, M Pennati, AM Gianni, C De Marco, MG Daidone, C Argueta, Y Landesman, N Zaffaroni, A Satta
    Cells, 2020-10-02;9(10):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways
    Authors: J Dittmann, T Haydn, P Metzger, GA Ward, M Boerries, M Vogler, S Fulda
    Cell Death Differ., 2019-12-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells
    Authors: EB Jo, YS Lee, H Lee, JB Park, H Park, YL Choi, D Hong, SJ Kim
    BMC Cancer, 2019-05-24;19(1):496.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. miR-494 Sensitizes Gastric Cancer Cells to TRAIL Treatment Through Downregulation of Survivin
    Authors: S Xu, D Li, T Li, L Qiao, K Li, L Guo, Y Liu
    Cell. Physiol. Biochem., 2018-12-07;51(5):2212-2223.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  13. miR-128 Targets the SIRT1/ROS/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis
    Authors: B Lian, D Yang, Y Liu, G Shi, J Li, X Yan, K Jin, X Liu, J Zhao, W Shang, R Zhang
    Cell. Physiol. Biochem., 2018-09-26;49(6):2151-2162.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Imperatorin Targets MCL-1 to Sensitize CD133+ Lung Cancer Cells to ??-T Cell-Mediated Cytotoxicity
    Authors: C You, Y Yang, B Gao
    Cell. Physiol. Biochem., 2018-08-23;49(1):235-244.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  15. Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5
    Authors: Y Zhao, B Tian, Y Wang, H Ding
    Med. Sci. Monit., 2017-10-26;23(0):5096-5105.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Targeting Apoptotic Activity Against Prostate Cancer Stem Cells
    Authors: D Jaworska, E Szliszka
    Int J Mol Sci, 2017-07-29;18(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
    Authors: HD Singh, I Otano, K Rombouts, KP Singh, D Peppa, US Gill, K Böttcher, PTF Kennedy, J Oben, M Pinzani, H Walczak, G Fusai, WMC Rosenberg, MK Maini
    Sci Rep, 2017-07-17;7(1):5514.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. The role of selected flavonols in tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) expression on activated RAW 264.7 macrophages.
    Authors: Warat M, Sadowski T, Szliszka E, Krol W, Czuba Z
    Molecules, 2015-01-08;20(1):900-12.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  19. Soluble TRAIL is present at high concentrations in seminal plasma and promotes spermatozoa survival
    Authors: Giorgio Zauli, Claudio Celeghini, Lorenzo Monasta, Monica Martinelli, Stefania Luppi, Arianna Gonelli et al.
    REPRODUCTION
  20. Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages.
    Authors: Warat M, Szliszka E, Korzonek-Szlacheta I, Krol W, Czuba Z
    Int J Mol Sci, 2014-06-27;15(7):11510-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  21. Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines.
    Authors: Calzolari A, Saulle E, De Angelis M, Pasquini L, Boe A, Pelacchi F, Ricci-Vitiani L, Baiocchi M, Testa U
    PLoS ONE, 2014-04-16;9(4):e94438.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  22. TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells.
    Authors: Tang X, Lu J, Tu H, Huang K, Fu R, Cao G, Huang M, Cheng L, Dai L, Zhang L
    Anticancer Res, 2014-02-01;34(2):729-34.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  23. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
    Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo
    Stem Cells Transl Med, 2014-01-16;3(2):172-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  24. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.
    Authors: Gupta, Subash C, Francis, Sajin K, Nair, Mangalam, Mo, Yin-Yuan, Aggarwal, Bharat B
    J Biol Chem, 2013-09-27;288(45):32343-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  25. Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
    Authors: Gojo I, Tan M, Fang H, Sadowska M, Lapidus R, Baer M, Carrier F, Beumer J, Anyang B, Srivastava R, Espinoza-Delgado I, Ross D
    Clin Cancer Res, 2013-02-12;19(7):1838-51.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Flow Cytometry
  26. Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis.
    Authors: Hong S, Kim H, Kim J, Ha H, Kim Y, Bae E, Kim T, Lee K, Kim S
    J Biol Chem, 2012-12-19;288(5):3560-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  27. Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell-mediated deletion.
    Authors: Peppa, Dimitra, Gill, Upkar S, Reynolds, Gary, Easom, Nicholas, Pallett, Laura J, Schurich, Anna, Micco, Lorenzo, Nebbia, Gaia, Singh, Harsimra, Adams, David H, Kennedy, Patrick, Maini, Mala K
    J Exp Med, 2012-12-17;210(1):99-114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  28. Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells
    Authors: Jun-Jie Chen, H.-C. Jennifer Shen, Leslie A. Rivera Rosado, Yaqin Zhang, Xu Di, Baolin Zhang
    Oncotarget
  29. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity.
    Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
    J. Immunol., 2012-01-09;188(4):1583-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  30. WEE1 Inhibition Sensitizes Basal Breast Cancer Cells to TRAIL-Induced Apoptosis
    Authors: Sireesha V. Garimella, Andrea Rocca, Stanley Lipkowitz
    Molecular Cancer Research
  31. TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms
    Authors: H Rauert, T Stühmer, R Bargou, H Wajant, D Siegmund
    Cell Death & Disease
  32. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells.
    Authors: Szliszka E, Helewski KJ, Mizgala E, Krol W
    Int. J. Oncol., 2011-07-06;39(4):771-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  33. Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
    Authors: Kang Z, Chen J, Yu Y, Li B, Sun S, Zhang B, Cao L
    Clin Cancer Res, 2011-03-08;17(10):3181-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  34. Cisplatin sensitizes human hepatocellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5
    Authors: Bo Zhang, Hong Shan, Dan Li, Zheng-Ran Li, Kang-Shun Zhu, Zai-Bo Jiang et al.
    Oncology Reports
  35. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
    Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS
    Cancer Res., 2008-12-01;68(23):9614-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  36. Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
    Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
    Stem Cells, 2008-09-04;26(11):2955-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  37. TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5.
    Authors: Wu CH, Kao CH, Safa AR
    Hum. Gene Ther., 2008-07-01;19(7):731-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  38. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
    Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK
    J. Exp. Med., 2007-03-12;204(3):667-80.
    Species: Human
    Sample Types: Serum
    Applications: Flow Cytometry
  39. Tubulin couples death receptor 5 to regulate apoptosis.
    Authors: Twomey JD, Zhao L, Luo S et al.
    Oncotarget
  40. A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance
    Authors: Dimberg L, Towers CG, Behbakht K et al.
    Mol. Cancer Res
  41. Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model
    Authors: Twomey JD, Zhang B.
    Cancers (Basel)

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