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Human Sigma-1 R Alexa Fluor® 700-conjugated Antibody

Catalog #: FAB1076N Datasheet
Recombinant Monoclonal Antibody
Catalog # Availability Size / Price Qty
FAB1076N-100UG
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Human Sigma-1 R Alexa Fluor® 700-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Sigma-1 R in direct ELISAs.
Source
Monoclonal Rabbit IgG Clone # 1319A
Purification
Protein A or G purified
Immunogen
Synthetic peptide containing human Sigma-1 R
Accession # Q99720
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 700 (Excitation= 675-700 nm, Emission= 723 nm)

Applications

Recommended Concentration
Sample
Immunocytochemistry
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Sigma-1 R

Sigma non-opioid intracellular receptor 1 (SIGMAR1, OPRS1 or Sigma1 receptor) is a 223 aminoacids (aa), 25KDa chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. Sigmar1 functions as a lipid transporter and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. In Human, at least 4 other isoforms have been found, ranging from 12-22 KDa.

Long Name
Sigma Non-opioid Intracellular Receptor 1
Entrez Gene IDs
10280 (Human); 18391 (Mouse); 29336 (Rat)
Alternate Names
Aging-associated gene 8 protein; ALS16; FLJ25585; hSigmaR1; OPRS1; SIG-1R; sigma 1; Sigma 1-type opioid receptor; sigma non-opioid intracellular receptor 1; Sigma-1 R; sigma1 receptor; Sigma1R; Sigma-1R; sigma1-receptor; SIGMAR1; SR31747 binding protein 1; SR31747-binding protein; SRBP; SR-BP; SR-BP1; SRBPMGC3851; type I sigma receptor

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