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Human S1P1/EDG-1 PE-conjugated Antibody

Catalog #: FAB2016P
5 Citations Datasheet
Clone 218713 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB2016P
Detection of S1P1/EDG‑1 in CHO Chinese Hamster Cell Line Transfected with Human S1P1/EDG-1 and eGFP by Flow Cytometry.
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Citations (5)
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Human S1P1/EDG-1 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human S1P1/EDG‑1 by flow cytometry.
Source
Monoclonal Mouse IgG2B Clone # 218713
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
NS0 mouse myeloma cell line transfected with human S1P1/EDG‑1
Met1-Ser382
Accession # P21453
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of S1P<sub>1</sub>/EDG-1 antibody in CHO Chinese Hamster Cell Line Transfected with Human S1P<sub>1</sub>/EDG-1 and eGFP antibody by Flow Cytometry. View Larger

Detection of S1P1/EDG‑1 in CHO Chinese Hamster Cell Line Transfected with Human S1P1/EDG-1 and eGFP by Flow Cytometry. CHO Chinese hamster ovary cell line transfected with either (A) human S1P1/EDG-1 or (B) irrelevant transfectants and eGFP were stained with Mouse Anti-Human S1P1/EDG-1 PE-conjugated Monoclonal Antibody (Catalog # FAB2016P). Quadrant markers were set based on control antibody staining (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: S1P1/EDG-1

S1P1, also known as EDG-1, is a member of the endothelial differentiation gene family. It is a high affinity G protein-coupled receptor for the bioactive lipid, Sphingosine-1-phosphate. S1P1 signaling regulates endothelial cell survival, cytoskeletal remodeling, chemotaxis, and angiogenesis.

Long Name
Endothelial Differentiation Gene 1
Entrez Gene IDs
1901 (Human); 13609 (Mouse)
Alternate Names
CD363 antigen; CD363; CHEDG1; D1S3362; EDG1; EDG-1; EDG1edg-1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121; S1P receptor 1; S1P receptor Edg-1; S1P1; S1P1ECGF1; S1PR1; sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor EDG1; Sphingosine 1-phosphate receptor Edg-1; sphingosine-1-phosphate receptor 1

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Citations for Human S1P1/EDG-1 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. A novel S1P1 modulator IMMH002 ameliorates psoriasis in multiple animal models
    Authors: J Jin, N Xue, Y Liu, R Fu, M Wang, M Ji, F Lai, J Hu, X Wang, Q Xiao, X Zhang, D Yin, L Bai, X Chen, S Rao
    Acta Pharm Sin B, 2019-11-14;10(2):276-288.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Fingolimod reduces circulating tight-junction protein levels and in vitro peripheral blood mononuclear cells migration in multiple sclerosis patients
    Authors: P Annunziata, C Cioni, G Masi, M Tassi, G Marotta, S Severi
    Sci Rep, 2018-10-18;8(1):15371.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.
    Authors: Borge M, Remes Lenicov F, Nannini P, de los Rios Alicandu M, Podaza E, Ceballos A, Fernandez Grecco H, Cabrejo M, Bezares R, Morande P, Oppezzo P, Giordano M, Gamberale R
    J Immunol, 2014-08-15;193(6):3165-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry.
    Authors: Llinas L, Lazaro A, de Salort J, Matesanz-Isabel J, Sintes J, Engel P
    Immunol. Lett., 2010-10-15;134(2):113-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases
    Authors: King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Mühle, Elina Ikonen, Ira Milosevic et al.
    eLife

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