Human S100A11 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: S100A11

S100A11 (also S100C and calgizzarin) is a 10-12 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins.  It is produced by smooth muscle and keratinocytes. Intracellularly, it suppresses growth; extracellularly, it exists as both a monomer, homodimer, and heterodimer with S100B, binds to RAGE, induces EGF, and promotes cell growth.  Human S100A11 is 105 amino acids (aa) in length.  It contains two EF-hand motifs (aa 13-49 and 55-90) and one high-affinity Ca-binding site (aa 68-79), and binds annexin I with its C-terminal half.  There may be one alternative splice form that apparently contains a series of mutations over aa 61-79 and shows 90% overall aa identity to the standard form.  Full-length human S100A11 shares 78% and 82% aa identity with mouse and porcine S100A11, respectively.

Product Datasheets

Related Research Areas

• Calcium-binding Proteins and Related Molecules
• Inflammatory Mediators