Human Progesterone R B/NR3C3 Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Progesterone R/NR3C3

Progesterone Receptor B (PR-B) is a 118 kDa member of the NR3 subfamily within the nuclear hormone receptor family of proteins. It is expressed in several tissues, including female reproductive organs as well as neurons throughout the CNS. PR-B is particularly important in the mammary gland where it mediates proliferative responses to progesterone. Human PR-B contains an N-terminal regulatory region (aa1‑566), a DNA binding domain (aa 567‑639), and a steroid-binding region (aa 681‑933). Ligand binding induces a key phosphorylation event at Ser294 by ERK1/2.

Product Datasheets

Related Research Areas

• Cancer Biomarkers
• Gametes and Fertilization
• Steroid Hormone Receptors and Regulators
• Steroid Hormones and Bioactive Lipids
• Transcription Regulators in VSMC