Human Pro‑MMP‑7 Antibody Summary
AEYSLFPNSPKWTSKV, Ala93-Val108
Accession # P09237
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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MMP‑7 in Human Pancreatic Cancer Tissue. MMP-7 was detected in immersion fixed paraffin-embedded sections of human pancreatic cancer tissue using Human Pro-MMP-7 Monoclonal Antibody (Catalog # MAB907) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-7
Matrix metalloproteinases (MMPs) are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-7 (matrilysin) is expressed in epithelial cells of normal and diseased tissues, and is capable of digesting a large series of proteins of the extracellular matrix including collagen IV and X, gelatin, casein, laminin, aggrecan, entactin, elastin and versican. MMP-7 is implicated in the activation of other proteinases such as plasminogen, MMP-1, MMP-2, and MMP-9. In addition to its roles in connective tissue remodeling and cancer, MMP-7 also regulates intestinal alpha -defensin activation in innate host defense, releases tumor necrosis factor-alpha in a model of herniated disc resorption, and cleaves FasL to generate a soluble form in a model of prostate involution. Structurally, MMP-7 is the smallest of the MMPs and consists of two domains: a pro-domain that is cleaved upon activation and a catalytic domain containing the zinc-binding site.
Product Datasheets
Citations for Human Pro‑MMP‑7 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer
Authors: Elena Kostova, Maja Slaninka-Miceska, Nikola Labacevski, Krume Jakovski, Jasmina Trojachanec, Emilija Atanasovska et al.
Vojnosanitetski pregled
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Matrilysin (MMP-7) Inhibition of BMP-7 Induced Renal Tubular Branching Morphogenesis Suggests a Role in the Pathogenesis of Human Renal Dysplasia
Authors: John K. McGuire, Susanna Harju-Baker, Cliff Rims, Joong-Hyuk Sheen, Helen Liapis
Journal of Histochemistry & Cytochemistry
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GPI-anchored TIMP-1 treatment renders renal cell carcinoma sensitive to FAS-meditated killing.
Authors: Djafarzadeh R, Noessner E, Engelmann H
Oncogene, 2006;25(10):1496-508.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot
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