Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody

Catalog #: BAF149 Datasheet

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BAF149

All Presenilin-1 Antibodies

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Human Presenilin-1 N-Terminal Fragment Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Presenilin‑1 N‑Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human Presenilin‑1 C‑Terminal Fragment (aa 298‑407) and recombinant human Presenilin‑2 C‑Terminal Fragment (aa 1‑80) is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Presenilin‑1
Lys1-Lys80
Accession # P49768

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human Presenilin‑1 N-Terminal Fragment

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin-1 is a catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). In addition it is required for normal embryonic brain and skeleton development, and for normal angiogenesis.

Entrez Gene IDs

5663 (Human)

Alternate Names

AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182