Human Presenilin-1 N-Terminal Fragment Antibody

Catalog #: MAB1491 Datasheet

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MAB1491
MAB1491-SP

All Presenilin-1 Antibodies

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Human Presenilin-1 N-Terminal Fragment Antibody Summary

Species Reactivity

Human

Specificity

Detects human Presenilin‑1 N-Terminal Fragment in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Presenilin-1 C-Terminal Fragment, rhPresenilin-2 C-Terminal Fragment, or rhPresenilin-2 N-Terminal Fragment is observed.

Source

Monoclonal Mouse IgG_2A Clone # 121130

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

E. coli-derived recombinant human Presenilin‑1 N-Terminal Fragment
Met1-Lys80
Accession # P49768

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human Presenilin‑1 N-Terminal Fragment

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin‑1 (PS-1) is a 467 amino acid multipass lysosomal membrane protein that is a component of the gamma secretase complex. It is cleaved by endoproteolysis at or near amino acid 298 to generate N‑ and C‑terminal fragments. Some mutations in PS-1 are associated with the risk of early onset familial Alzheimer's disease.

Entrez Gene IDs

5663 (Human)

Alternate Names

AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182