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Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

Catalog #: BAF166
1 Citation Datasheet
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BAF166
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Citations (1)
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Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human Presenilin‑1 C-Terminal Fragment in Western blots. In Western blots, less than 1% cross‑reactivity with recombinant human (rh) Presenilin‑1 N-Terminal Fragment  (aa 1‑80) and rhPresenilin‑2 C-Terminal Fragment  (aa 322‑388) is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human Presenilin-1
aa 298-407
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human Presenilin‑1 C-Terminal Fragment
Immunohistochemistry
5-15 µg/mL
Immersion fixed paraffin-embedded sections of human brain (hippocampus)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Presenilin-1

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

Entrez Gene IDs
5663 (Human)
Alternate Names
AD3EC 3.4.23.-; Alzheimer disease 3; EC 3.4.23; FAD; presenilin 1; Presenilin1; Presenilin-1; Protein S182; PS-1; PS1presenilin-1; PSEN1; PSNL1; S182

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Citation for Human Presenilin-1 C-Terminal Fragment Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
    Authors: Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O
    J. Biol. Chem., 2006-06-30;281(36):26400-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC

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