Human Phospho-EGFR/ErbB1 (Y1068) Alexa Fluor® 488-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
Background: EGFR
Epidermal growth factor receptor (EGF R, also known as ErbB1 and HER1) is the founding member of the ErbB family of receptor tyrosine kinases. Ligand binding induces receptor dimerization and autophosphorylation on multiple tyrosine residues. Phosphorylation at Tyr 1068 allows binding of the SH2 domain of the cytosolic adaptor Grb2. This binding results in Ras activation.
Product Datasheets
Product Specific Notices
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Citations for Human Phospho-EGFR/ErbB1 (Y1068) Alexa Fluor® 488-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Quantification of ligand and mutation-induced bias in EGFR phosphorylation in direct response to ligand binding
Authors: Wirth, D;Özdemir, E;Hristova, K;
Nature communications
Species: Chinese Hamster
Sample Types: Vesicles
Applications: Bioassay -
Drug-Induced Resistance and Phenotypic Switch in Triple-Negative Breast Cancer Can Be Controlled via Resolution and Targeting of Individualized Signaling Signatures
Authors: S Vasudevan, IA Adejumobi, H Alkhatib, S Roy Chowdh, S Stefansky, AM Rubinstein, N Kravchenko
Cancers, 2021-10-06;13(19):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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