Home / PDGF R beta / Human PDGF R beta Antibody

Human PDGF R beta Antibody

Catalog #: AF385
61 Citations 1 Review Datasheet
Catalog # Availability Size / Price Qty
AF385
AF385-SP
PDGF R beta in Human Breast Cancer Tissue.
11 Images
Product Details
Citations (61)
FAQs
Supplemental Products
Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human PDGF R beta Antibody Summary

Species Reactivity
Human
Specificity
Detects human PDGF R beta in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human PDGF R beta
Leu33-Phe530 (Glu241Asp)
Accession # P09619
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
2 µg/mL
SH-SY5Y human neuroblastoma cell line and U2OS human osteosarcoma cell line
Flow Cytometry
0.25 µg/106 cells
BUD‑8 human fibroblast cell line, U87MG and U118MG

Immunohistochemistry
5-15 µg/mL
See below
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Neutralization
Measured by its ability to neutralize PDGF R beta inhibition of PDGF-BB-dependent proliferation in the NR6R‑3T3 mouse fibroblast cell line. The Neutralization Dose (ND50) is typically 10-40 µg/mL in the presence of 2 μg/mL Recombinant Human PDGF R beta Fc Chimera and 4 ng/mL Recombinant Human PDGF-BB.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry PDGF R beta antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

PDGF R beta in Human Breast Cancer Tissue. PDGF R beta was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 15 µg/mL Goat Anti-Human PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF385) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Neutralization PDGF R beta Inhibition of PDGF-BB-dependent Cell Proliferation and Neutralization by Human PDGF R beta Antibody. View Larger

PDGF R beta Inhibition of PDGF-BB-dependent Cell Proliferation and Neutralization by Human PDGF R beta Antibody. Recombinant Human PDGF R beta Fc Chimera (385-PR) inhibits Recombinant Human PDGF-BB (220-BB) induced proliferation in the NR6R-3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human PDGF-BB (4 ng/mL) activity elicited by Recombinant Human PDGF R beta Fc Chimera (2 µg/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF385). The ND50 is typically 10-40 µg/mL.

Flow Cytometry View Larger

Detection of PDGF R beta in U87MG cells by Flow Cytometry. U87MG cells were stained with Goat Anti-Human PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF385, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry View Larger

Detection of PDGF R beta in U118MG cells by Flow Cytometry. U118MG cells were stained with Goat Anti-Human PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF385, filled histogram) or isotype control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry Detection of Human PDGF R beta by Flow Cytometry View Larger

Detection of Human PDGF R beta by Flow Cytometry Co-expression of EC marker and PDGFR beta after EPC-CM incubation.Co-expression of vWF and PDGFR beta was measured using dual color FACS analysis. HUVEC were kept in control medium containing only 1% FCS or EPC-CM for 24 h before the measurement. HUVEC incubated in control medium showed only a fractional amount of vWF+/PDGFR beta + cells (A). After EPC-CM exposure the proportion of vWF+/PDGFR beta + double positive population was significantly increased, suggesting a strong phenotype shift of endothelial cells towards PDGFR beta + (B). The addition of neutralizing antibody AF385 did not block the upreguation of the PDGFR beta by EPC-CM stimulation (C). However, such enhanced PDGFR beta expression could not be evoked by solely adding 100 ng/ml (D) or 100 pg/ml (E) rhPDGF-BB to the control medium. *, P<0.01 compared to controls. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0014107), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot View Larger

Detection of Human PDGF R beta by Western Blot. Western Blot shows lysates of SH‑SY5Y human neuroblastoma cell line and U2OS human osteosarcoma cell line. PVDF membrane was probed with 2 µg/ml of Goat Anti-Human PDGF R beta Antigen Affinity-purified Polyclonal Antibody (Catalog # AF385) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for PDGF R beta at approximately 190 kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1.

Immunohistochemistry Detection of Mouse PDGF R beta by Immunohistochemistry View Larger

Detection of Mouse PDGF R beta by Immunohistochemistry Pericyte soma on WM capillaries demonstrated by immunofluorescence. A–F. PDGFR‐ beta (red) and COL4 (green) immunofluorescence staining with nuclei (DAPI) (blue). A,B. Low‐ and high‐power images showing capillary segments (arrowheads) with overlapping PDGFR‐ beta (red), COL4 (green) and DAPI (blue). C. Same vessel segment as B with PDGFR‐ beta (red) and COL4 (green); D. COL4 (green) and DAPI (blue); E. PDGFR‐ beta (red) and DAPI (blue). F. Another capillary segment with PDGFR‐ beta (red), COL4 (green) and DAPI (blue) clearly showing pericyte cell body. G–J. Images taken by a confocal microscope showing pericyte cell bodies (arrows) with nuclear stain (DAPI). Capillaries and pericyte processes are revealed by COL4 and PDGFR‐ beta (red) immunoreactivities. Magnification bars: A = 50 µm, F, J = 10 µm. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/32705757), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse PDGF R beta by Immunohistochemistry View Larger

Detection of Mouse PDGF R beta by Immunohistochemistry Pericyte soma on WM capillaries demonstrated by immunofluorescence. A–F. PDGFR‐ beta (red) and COL4 (green) immunofluorescence staining with nuclei (DAPI) (blue). A,B. Low‐ and high‐power images showing capillary segments (arrowheads) with overlapping PDGFR‐ beta (red), COL4 (green) and DAPI (blue). C. Same vessel segment as B with PDGFR‐ beta (red) and COL4 (green); D. COL4 (green) and DAPI (blue); E. PDGFR‐ beta (red) and DAPI (blue). F. Another capillary segment with PDGFR‐ beta (red), COL4 (green) and DAPI (blue) clearly showing pericyte cell body. G–J. Images taken by a confocal microscope showing pericyte cell bodies (arrows) with nuclear stain (DAPI). Capillaries and pericyte processes are revealed by COL4 and PDGFR‐ beta (red) immunoreactivities. Magnification bars: A = 50 µm, F, J = 10 µm. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/32705757), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Rhesus Macaque PDGF R beta by Immunohistochemistry View Larger

Detection of Rhesus Macaque PDGF R beta by Immunohistochemistry Expression of MCT8 and OATP1C1 in blood vessels and brain barriers in the human and macaque basal ganglia and adjacent choroid plexus. (A) Representative brightfield photomicrograph shows immunostaining for MCT8 in the human putamen. Note that an MCT8 immunopositive signal is observed along the capillary wall (red arrowhead), fibers (green arrowhead), and “bump-on-a-log” morphology pericytelike cells (white arrowhead). (B–H) Representative confocal microscope compositions from multiple-stained sections for MCT8 (green), the endothelial marker UEA-I (red), and the vascular and pericyte biomarker PDGFR-beta (purple) in human and macaque caudate nucleus. Merged image (E,H) shows the colocalization of all signals. (B–E) Coexpression of MCT8, UEA-I, and PDGFR-beta is observed in a vessel, while coexpression of MCT8 and PDGFR-beta but not UEA-I is observed in a capillary-associated pericyte (white arrowheads) in humans. (F–H) Coexpression of MCT8 and PDGFR-beta in a vessel and pericytelike cells (white arrowheads) in macaques. Counterstaining with DAPI (blue) shows nuclei of all cells. (I,J) Representative brightfield photomicrographs show immunostaining for MCT8 (I) and OATP1C1 (J) in the macaque choroid plexus at the lateral ventricle. Black arrowheads point to ependymocytes. Cd: caudate nucleus, Put: putamen, PDGFR-beta : platelet-derived growth factor receptor-beta, UEA-I: Ulex europaeus agglutinin-I. Scale bar = 10 μm (A–H) and 50 μm (I,J). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/37298594), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Human PDGF R beta by Immunohistochemistry View Larger

Detection of Human PDGF R beta by Immunohistochemistry Expression of MCT8 and OATP1C1 in blood vessels and brain barriers in the human and macaque basal ganglia and adjacent choroid plexus. (A) Representative brightfield photomicrograph shows immunostaining for MCT8 in the human putamen. Note that an MCT8 immunopositive signal is observed along the capillary wall (red arrowhead), fibers (green arrowhead), and “bump-on-a-log” morphology pericytelike cells (white arrowhead). (B–H) Representative confocal microscope compositions from multiple-stained sections for MCT8 (green), the endothelial marker UEA-I (red), and the vascular and pericyte biomarker PDGFR-beta (purple) in human and macaque caudate nucleus. Merged image (E,H) shows the colocalization of all signals. (B–E) Coexpression of MCT8, UEA-I, and PDGFR-beta is observed in a vessel, while coexpression of MCT8 and PDGFR-beta but not UEA-I is observed in a capillary-associated pericyte (white arrowheads) in humans. (F–H) Coexpression of MCT8 and PDGFR-beta in a vessel and pericytelike cells (white arrowheads) in macaques. Counterstaining with DAPI (blue) shows nuclei of all cells. (I,J) Representative brightfield photomicrographs show immunostaining for MCT8 (I) and OATP1C1 (J) in the macaque choroid plexus at the lateral ventricle. Black arrowheads point to ependymocytes. Cd: caudate nucleus, Put: putamen, PDGFR-beta : platelet-derived growth factor receptor-beta, UEA-I: Ulex europaeus agglutinin-I. Scale bar = 10 μm (A–H) and 50 μm (I,J). Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/37298594), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunohistochemistry Detection of Mouse PDGF R beta by Immunohistochemistry View Larger

Detection of Mouse PDGF R beta by Immunohistochemistry Pericyte soma on WM capillaries demonstrated by immunofluorescence. A–F. PDGFR‐ beta (red) and COL4 (green) immunofluorescence staining with nuclei (DAPI) (blue). A,B. Low‐ and high‐power images showing capillary segments (arrowheads) with overlapping PDGFR‐ beta (red), COL4 (green) and DAPI (blue). C. Same vessel segment as B with PDGFR‐ beta (red) and COL4 (green); D. COL4 (green) and DAPI (blue); E. PDGFR‐ beta (red) and DAPI (blue). F. Another capillary segment with PDGFR‐ beta (red), COL4 (green) and DAPI (blue) clearly showing pericyte cell body. G–J. Images taken by a confocal microscope showing pericyte cell bodies (arrows) with nuclear stain (DAPI). Capillaries and pericyte processes are revealed by COL4 and PDGFR‐ beta (red) immunoreactivities. Magnification bars: A = 50 µm, F, J = 10 µm. Image collected and cropped by CiteAb from the following open publication (https://pubmed.ncbi.nlm.nih.gov/32705757), licensed under a CC-BY license. Not internally tested by R&D Systems.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Loading...
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: PDGF R beta

PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF‑BB, and PDGF‑AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. Both PDGF R alpha and PDGF R beta  are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF, and Flt-3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and hetero-dimerization and signal transduction. The expression of the alpha and beta receptors is independently regulated in various cell types. Recombinant soluble PDGF R beta binds PDGF with high affinity and is potent PDGF antagonist.

References
  1. Heldin, C.H. and L. Claesson-Welsh (1994) in Guidebook to Cytokines and Their Receptors, Nicola, N.A. ed. Oxford University Press, New York, p. 202.
Long Name
Platelet-derived Growth Factor Receptor beta
Entrez Gene IDs
5159 (Human); 18596 (Mouse); 24629 (Rat)
Alternate Names
beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b antigen; CD140b; EC 2.7.10; EC 2.7.10.1; JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; PDGF-R-beta; platelet-derived growth factor receptor, beta polypeptide

Product Datasheets

You must select a language.

x
Product Datasheet

Citations for Human PDGF R beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

61 Citations: Showing 1 - 10
Filter your results:

Filter by:

  1. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network
    Authors: JH Low, P Li, EGY Chew, B Zhou, K Suzuki, T Zhang, MM Lian, M Liu, E Aizawa, C Rodriguez, KSM Yong, Q Chen, JM Campistol, M Fang, CC Khor, JN Foo, JC Izpisua Be, Y Xia
    Cell Stem Cell, 2019-07-11;0(0):.
  2. Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud
    Authors: Shi, M;Crouse, B;Sundaram, N;Shakked, NP;Ester, L;Zhang, W;Janakiram, V;Kopan, R;Helmrath, MA;Bonventre, JV;McCracken, KW;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Organoid
    Applications: Immunocytochemistry
  3. Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo
    Authors: Liu, M;Zhang, C;Gong, X;Zhang, T;Lian, MM;Chew, EGY;Cardilla, A;Suzuki, K;Wang, H;Yuan, Y;Li, Y;Naik, MY;Wang, Y;Zhou, B;Soon, WZ;Aizawa, E;Li, P;Low, JH;Tandiono, M;Montagud, E;Moya-Rull, D;Rodriguez Esteban, C;Luque, Y;Fang, M;Khor, CC;Montserrat, N;Campistol, JM;Izpisua Belmonte, JC;Foo, JN;Xia, Y;
    Cell stem cell
    Species: Human
    Sample Types: Organoid
    Applications: Immunohistochemistry
  4. Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
    Authors: Monteil, V;Kwon, H;John, L;Salata, C;Jonsson, G;Vorrink, SU;Appelberg, S;Youhanna, S;Dyczynski, M;Leopoldi, A;Leeb, N;Volz, J;Hagelkruys, A;Kellner, MJ;Devignot, S;Michlits, G;Foong-Sobis, M;Weber, F;Lauschke, VM;Horn, M;Feldmann, H;Elling, U;Penninger, JM;Mirazimi, A;
    Nature communications
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  5. Mass Spectrometry Reveals that Oxysterols are Secreted from Non-Alcoholic Fatty Liver Disease Induced Organoids
    Authors: Kømurcu, KS;Wilhelmsen, I;Thorne, JL;Krauss, S;Wilson, SR;Aizenshtadt, A;Røberg-Larsen, H;
    The Journal of steroid biochemistry and molecular biology
    Species: Human
    Sample Types: Organoid
    Applications: Immunohistochemistry
  6. Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains
    Authors: Wang, T;Wang, Y;Montero-Pedrazuela, A;Prensa, L;Guadaño-Ferraz, A;Rausell, E;
    International journal of molecular sciences
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Primate - Saimiri sciureus (South American Squirrel Monkey), Human
    Sample Types: Whole Tissue
    Applications: IHC
  7. Combinatorial Microgels for 3D ECM Screening and Heterogeneous Microenvironmental Culture of Primary Human Hepatic Stellate Cells
    Authors: Ryoo, H;Underhill, GH;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  8. Protocol to generate cardiac pericytes from human induced pluripotent stem cells
    Authors: Shen M, Zhao SR, Khokhar Y et al.
    STAR protocols
  9. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction
    Authors: Chanawee Hirunpattarasilp, Greg James, Jaturon Kwanthongdee, Felipe Freitas, Jiandong Huo, Huma Sethi et al.
    Brain
  10. NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy
    Authors: Choudhury, A;Cady, M;Lucas, C;Najem, H;Phillips, J;Palikuqi, B;Zakimi, N;Joseph, T;Birrueta, J;Chen, W;Bush, N;Hervey-Jumper, S;Klein, O;Toedebusch, C;Horbinski, C;Magill, S;Bhaduri, A;Perry, A;Dickinson, P;Heimberger, A;Ashworth, A;Crouch, E;Raleigh, D;
    bioRxiv
    Species:  Human
    Sample Types: Whole Tissue
    Applications: IHC
  11. Human pericytes degrade diverse alpha-synuclein aggregates
    Authors: BV Dieriks, B Highet, A Alik, T Bellande, TJ Stevenson, V Low, TI Park, J Correia, P Schweder, RLM Faull, R Melki, MA Curtis, M Dragunow
    PLoS ONE, 2022-11-18;17(11):e0277658.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  12. Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue
    Authors: Elizabeth Cooper, Zoe Woolf, Molly E V Swanson, Jason Correia, Patrick Schweder, Edward Mee et al.
    Neuro-Oncology Advances
  13. Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease
    Authors: Jessica Lisa Littau, Lina Velilla, Yoshiki Hase, Nelson David Villalba‐Moreno, Christian Hagel, Dagmar Drexler et al.
    Brain Pathology
  14. Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice
    Authors: T Zhou, Y Li, X Li, F Zeng, Y Rao, Y He, Y Wang, M Liu, D Li, Z Xu, X Zhou, S Du, F Niu, J Peng, X Mei, SJ Ji, Y Shu, W Lu, F Guo, T Wu, TF Yuan, Y Mao, B Peng
    Nature Communications, 2022-10-24;13(1):6233.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  15. miR-181a/b downregulation: a mutation-independent therapeutic approach for inherited retinal diseases
    Authors: S Carrella, M Di Guida, S Brillante, D Piccolo, L Ciampi, I Guadagnino, J Garcia Piq, M Pizzo, E Marrocco, M Molinari, G Petrogiann, S Barbato, Y Ezhova, A Auricchio, B Franco, E De Leonibu, EM Surace, A Indrieri, S Banfi
    Embo Molecular Medicine, 2022-10-04;0(0):e15941.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  16. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair
    Authors: Gupta N, Matsumoto T, Hiratsuka K et al.
    Science Translational Medicine
  17. Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
    Authors: Niki Sarri, Kehuan Wang, Maria Tsioumpekou, Casimiro Castillejo-López, Johan Lennartsson, Carl-Henrik Heldin et al.
    Cellular and Molecular Life Sciences
  18. PDGF-D−PDGFR beta signaling enhances IL-15–mediated human natural killer cell survival
    Authors: Shoubao Ma, Tingting Tang, Xiaojin Wu, Anthony G. Mansour, Ting Lu, Jianying Zhang et al.
    Proceedings of the National Academy of Sciences
  19. Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis
    Authors: SF Mause, E Ritzel, A Deck, F Vogt, EA Liehn
    International Journal of Molecular Sciences, 2022-01-14;23(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  20. Pericytes as mediators of infiltration of macrophages in multiple sclerosis
    Authors: DK Kaushik, A Bhattachar, BM Lozinski, V Wee Yong
    Journal of Neuroinflammation, 2021-12-24;18(1):301.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  21. Loss with ageing but preservation of frontal�cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer's disease
    Authors: R Ding, Y Hase, M Burke, V Foster, W Stevenson, T Polvikoski, RN Kalaria
    Acta neuropathologica communications, 2021-08-02;9(1):130.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  22. Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease
    Authors: H Shi, Y Koronyo, DT Fuchs, J Sheyn, K Wawrowsky, S Lahiri, KL Black, M Koronyo-Ha
    Acta Neuropathol Commun, 2020-11-23;8(1):202.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  23. ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma
    Authors: E Aladowicz, L Granieri, F Marocchi, S Punzi, G Giardina, PF Ferrucci, G Mazzarol, M Capra, G Viale, S Confalonie, S Gandini, F Lotti, L Lanfrancon
    Cancers (Basel), 2020-11-13;12(11):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  24. Loss of capillary pericytes and the blood–brain barrier in white matter in poststroke and vascular dementias and Alzheimer’s disease
    Authors: Ren Ding, Yoshiki Hase, Kamar E. Ameen‐Ali, Michael Ndung'u, William Stevenson, Joseph Barsby et al.
    Brain Pathology
  25. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon
    Authors: B Di Marco, EE Crouch, B Shah, C Duman, MF Paredes, C Ruiz de Al, EJ Huang, J Alfonso
    Cell Rep, 2020-10-13;33(2):108256.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  26. Cell populations and muscle fiber morphology associated with acute and chronic muscle degeneration in lumbar spine pathology
    Authors: Bahar Shahidi, Michael C. Gibbons, Mary Esparza, Vinko Zlomislic, Richard Todd Allen, Steven R. Garfin et al.
    JOR SPINE
  27. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid
    Authors: Melanie D. Sweeney, Abhay P. Sagare, Maricarmen Pachicano, Michael G. Harrington, Elizabeth Joe, Helena C. Chui et al.
    Alzheimer's & Dementia
  28. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke
    Authors: L Kang, H Yu, X Yang, Y Zhu, X Bai, R Wang, Y Cao, H Xu, H Luo, L Lu, MJ Shi, Y Tian, W Fan, BQ Zhao
    Nat Commun, 2020-05-19;11(1):2488.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  29. Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina
    Authors: Haoshen Shi, Yosef Koronyo, Altan Rentsendorj, Giovanna C. Regis, Julia Sheyn, Dieu-Trang Fuchs et al.
    Acta Neuropathologica
  30. A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain
    Authors: R Rust, T Kirabali, L Grönnert, B Dogancay, YDP Limasale, A Meinhardt, C Werner, B Laviña, L Kulic, RM Nitsch, C Tackenberg, ME Schwab
    Front Neurosci, 2020-03-20;14(0):244.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  31. The amyloid-beta degradation intermediate Abeta34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease
    Authors: T Kirabali, S Rigotti, A Siccoli, F Liebsch, A Shobo, C Hock, RM Nitsch, G Multhaup, L Kulic
    Acta Neuropathol Commun, 2019-12-03;7(1):194.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC, Western Blot
  32. Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL
    Authors: RM Rajani, J Ratelade, V Domenga-De, Y Hase, H Kalimo, RN Kalaria, A Joutel
    Acta Neuropathol Commun, 2019-11-21;7(1):187.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  33. Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction
    Authors: Daniel A. Nation, Melanie D. Sweeney, Axel Montagne, Abhay P. Sagare, Lina M. D’Orazio, Maricarmen Pachicano et al.
    Nature Medicine
  34. Human blood vessel organoids as a model of diabetic vasculopathy
    Authors: Reiner A. Wimmer, Alexandra Leopoldi, Martin Aichinger, Nikolaus Wick, Brigitte Hantusch, Maria Novatchkova et al.
    Nature
  35. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability
    Authors: EA Winkler, H Birk, JK Burkhardt, X Chen, JK Yue, D Guo, WC Rutledge, GF Lasker, C Partow, T Tihan, EF Chang, H Su, H Kim, BP Walcott, MT Lawton
    J. Neurosurg., 2018-12-01;0(0):1-11.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  36. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-?42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
    Authors: Q Ma, Z Zhao, AP Sagare, Y Wu, M Wang, NC Owens, PB Verghese, J Herz, DM Holtzman, BV Zlokovic
    Mol Neurodegener, 2018-10-19;13(1):57.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  37. Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling
    Authors: T Liang, L Zhu, W Gao, M Gong, J Ren, H Yao, K Wang, D Shi
    FEBS Open Bio, 2017-10-16;7(11):1722-1736.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  38. Transcriptome analysis of PDGFR?+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFR?+ cell hyperplasia
    Authors: SE Ha, MY Lee, M Kurahashi, L Wei, BG Jorgensen, C Park, PJ Park, D Redelman, KC Sasse, LS Becker, KM Sanders, S Ro
    PLoS ONE, 2017-08-14;12(8):e0182265.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  39. A tissue-specific role for intraflagellar transport genes during craniofacial development
    Authors: EN Schock, JN Struve, CF Chang, TJ Williams, J Snedeker, AC Attia, RW Stottmann, SA Brugmann
    PLoS ONE, 2017-03-27;12(3):e0174206.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Endothelial Cells from Capillary Malformations Are Enriched for Somatic GNAQ Mutations
    Authors: Javier A. Couto, Lan Huang, Matthew P. Vivero, Nolan Kamitaki, Reid A. Maclellan, John B. Mulliken et al.
    Plastic and Reconstructive Surgery
  41. Shedding of soluble platelet-derived growth factor receptor-beta from human brain pericytes
    Authors: Abhay P. Sagare, Melanie D. Sweeney, Jacob Makshanoff, Berislav V. Zlokovic
    Neuroscience Letters
  42. Immunolocalization of platelet-derived growth factor receptor-beta (PDGFR-beta ) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    Authors: Lucinda J.L. Craggs, Richard Fenwick, Arthur E. Oakley, Masafumi Ihara, Raj N. Kalaria
    Neuropathology and Applied Neurobiology
  43. Designing and troubleshooting immunopanning protocols for purifying neural cells
    Authors: Ben A Barres
    Cold Spring Harb Protoc
  44. Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
    Authors: Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G
    J Biol Chem, 2014-06-27;289(33):22835-49.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  45. Growth factor receptor-Src-mediated suppression of GRK6 dysregulates CXCR4 signaling and promotes medulloblastoma migration.
    Authors: Yuan, Liangpin, Zhang, Hongying, Liu, Jingbo, Rubin, Joshua B, Cho, Yoon-Jae, Shu, Hui Kuo, Schniederjan, Matthew, MacDonald, Tobey J
    Mol Cancer, 2013-03-05;12(0):18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  46. Intrinsic regulation of hemangioma involution by platelet-derived growth factor
    Authors: E E Roach, R Chakrabarti, N I Park, E C Keats, J Yip, N G Chan et al.
    Cell Death & Disease
  47. Tissue transglutaminase promotes PDGF/PDGFR-mediated signaling and responses in vascular smooth muscle cells
    Authors: Evgeny A. Zemskov, Irina Mikhailenko, Elizabeth P. Smith, Alexey M. Belkin
    Journal of Cellular Physiology
  48. PDGFRbeta expression and function in fibroblasts derived from pluripotent cells is linked to DNA demethylation.
    J. Cell. Sci., 2012-02-17;125(0):2276-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  49. Endothelial Progenitor Cells Induce a Phenotype Shift in Differentiated Endothelial Cells towards PDGF/PDGFR beta Axis-Mediated Angiogenesis
    Authors: Moritz Wyler von Ballmoos, Zijiang Yang, Jan Völzmann, Iris Baumgartner, Christoph Kalka, Stefano Di Santo
    PLoS ONE
  50. Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase.
    Authors: Zemskov EA, Loukinova E, Mikhailenko I, Coleman RA, Strickland DK, Belkin AM
    J. Biol. Chem., 2009-04-22;284(24):16693-703.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  51. Inhibition of anastomotic intimal hyperplasia using a chimeric decoy strategy against NFkappaB and E2F in a rabbit model.
    Authors: Miyake T, Aoki M, Morishita R
    Cardiovasc. Res., 2008-05-31;79(4):706-14.
    Species: Rabbit
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  52. Pancreatic stellate cells: partners in crime with pancreatic cancer cells.
    Authors: Vonlaufen A, Joshi S, Qu C, Phillips PA, Xu Z, Parker NR, Toi CS, Pirola RC, Wilson JS, Goldstein D, Apte MV
    Cancer Res., 2008-04-01;68(7):2085-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  53. PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines.
    Authors: Li R, Maminishkis A, Wang FE, Miller SS
    Invest. Ophthalmol. Vis. Sci., 2007-12-01;48(12):5722-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  54. Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
    Authors: Ball SG, Shuttleworth CA, Kielty CM
    J. Cell Biol., 2007-04-30;177(3):489-500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  55. C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium.
    Authors: Dentelli P, Rosso A, Balsamo A, Colmenares Benedetto S, Zeoli A, Pegoraro M, Camussi G, Pegoraro L, Brizzi MF
    Blood, 2007-02-08;109(10):4264-71.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  56. Expression of growth factors and growth factor receptor in non-healing and healing ischaemic ulceration.
    Authors: Murphy MO, Ghosh J, Fulford P, Khwaja N, Halka AT, Carter A, Turner NJ, Walker MG
    Eur J Vasc Endovasc Surg, 2006-01-20;31(5):516-22.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  57. Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells.
    Authors: Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A
    Blood, 2005-12-01;107(5):1896-902.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  58. Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplasty.
    Authors: Nili N, Cheema AN, Giordano FJ, Barolet AW, Babaei S, Hickey R, Eskandarian MR, Smeets M, Butany J, Pasterkamp G, Strauss BH
    Am. J. Pathol., 2003-09-01;163(3):869-78.
    Species: Rabbit
    Sample Types: Cell Lysates
    Applications: Western Blot
  59. Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell chemotaxis.
    Authors: Campbell M, Allen WE, Silversides JA, Trimble ER
    Diabetes, 2003-02-01;52(2):519-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  60. Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells
    Nat Protoc, 2016-12-22;12(1):195-207.
  61. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells
    Authors: Coate KC, Cha J, Shrestha S et al.
    Int J Mol Sci

FAQs

No product specific FAQs exist for this product, however you may

View all Antibody FAQs
Loading...

Reviews for Human PDGF R beta Antibody

Average Rating: 4 (Based on 1 Review)

5 Star
0%
4 Star
100%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Human PDGF R beta Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Human PDGF R beta Antibody
By Anonymous on 04/30/2019
Application: WB Sample Tested: pericytes Species: Human and human pericytes
Western Blot Human PDGF R beta Antibody AF385