Human/Mouse/Rat STAT5b Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB15841S Datasheet

Recombinant Monoclonal Antibody

Catalog #	Availability	Size / Price	Qty
FAB15841S-100UG

All STAT5b Antibodies

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Human/Mouse/Rat STAT5b Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat STAT5b in Western blots.

Source

Monoclonal Rabbit IgG Clone # 1032E

Purification

Protein A or G purified

Immunogen

Human STAT5b synthetic peptide aa 777-787
Accession # P51692

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilution of this antibody should be experimentally determined.

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Knockout Validated

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: STAT5b

Signal Transduction and Activator of Transcription 5 (STAT5) is a member of the Jak/STAT signal transduction pathway and is activated by a variety of cytokines (IL‑22, IL-6, IFN-alpha ). STAT5 has two isoforms (A and B) that share 93% amino acid identity and bind the DNA consensus site TTCN₃GAA. STAT5 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, translocates to the nucleus and activates transcription of specific genes. STAT5 is involved in a wide array of biological processes ranging from regulating apoptosis to adult mammary gland proliferation, differentiation, and survival.

Long Name

Signal Transducer and Activator of Transcription 5b

Entrez Gene IDs

6777 (Human); 20851 (Mouse)

Alternate Names

signal transducer and activator of transcription 5B; STAT5; STAT5b; transcription factor STAT5B