Human/Mouse/Rat PKA RI beta Alexa Fluor® 405-conjugated Antibody

Catalog #: AF4177V Datasheet

Catalog #	Availability	Size / Price	Qty
AF4177V-100UG

All PKA RI beta Antibodies

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Human/Mouse/Rat PKA RI beta Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat PKA RI beta in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human (rh) PKA RI alpha or rhPKA RII beta is observed; cross-reactivity with PKA RII alpha is unknown.

Source

Polyclonal Sheep IgG

Immunogen

E. coli-derived recombinant human PKA RIÎ²
Met1-Val381
Accession # P31321

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Purity

Antigen Affinity-purified

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PKA RI beta

The cAMP-dependent protein kinase (PKA) holoenzyme is composed of two regulatory and two catalytic subunits, designated PKA R and PKA C, respectively. PKA R subunits exist as two classes, RI and RII, with each class containing two isoforms, alpha and beta. Upon PKA R subunit binding to the second messenger cAMP, active PKA C subunits are released, initiating a phosphorylation cascade that regulates such cellular functions as metabolism, ion transport, and gene transcription.

Long Name

cAMP-dependent Protein Kinase Regulatory Type I beta

Entrez Gene IDs

5575 (Human); 19085 (Mouse); 25521 (Rat)

Alternate Names

PKA RI beta; PRKAR1; PRKAR1B; RIbeta

Product Datasheets

Product Datasheet

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