Human/Mouse/Rat Phospho-PP2A (Y307), Catalytic Subunit Alexa Fluor® 594-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: PP2A

Protein Phosphatase 2A (PP2A) dephosphorylates serine and threonine residues in proteins. This ubiquitously expressed enzyme plays a critical role in modulating cell survival, growth factor responses, and neurotransmission. Phosphorylation near the C-terminus at Y307 of the catalytic subunit decreases the phosphatase activity of PP2A and reduces its ability to bind to proteins such as CD28 and the glutamate receptor GluR5. Phosphorylation of PP2A at Y307 is highest during M-phase and lowest during S-phase of the cell cycle. Transient PP2A phosphorylation at this site is also observed in growth factor-stimulated cells.

Product Datasheets

Related Research Areas

• Adhesion Molecules on Endothelial Cells
• Adhesion Molecules on VSMC
• Epigenetics
• Focal Adhesions
• Neurofibrillary Tangle Formation
• Phosphatases and Regulators
• Phosphatases in the Akt Pathway
• Search Kinases and Phosphatases