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Human/Mouse/Rat Activin A Quantikine ELISA Kit

Catalog #: DAC00B
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QC33: Quantikine Immunoassay Control Set 983 for H/M/R Activin A
Human/Mouse/Rat Activin A ELISA Standard Curve
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Summary Sample Values Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human/Mouse/Rat Activin A Quantikine ELISA Kit Summary

Assay Length
5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Saliva (50 uL)
Sensitivity
7.85 pg/mL
Assay Range
15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva)
Specificity
Natural and recombinant human, mouse, and rat Activin A
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.Cross-species reactivity not tested.
Interference
No significant interference observed with available related molecules.

Sample Values

Serum/Plasma/Saliva - Samples were evaluated for the presence of human/mouse/rat Activin A in this assay. No medical histories were available for the donors used in this study.

Human SamplesMean (pg/mL)Range (pg/mL)Standard Deviation (pg/mL)
Serum (n=35)352142-753129
EDTA plasma (n=35)319115-665124
Heparin plasma (n=35)31611-695126

Human SamplesMean of Detectable (pg/mL)% DetectableRange (pg/mL)
Saliva (n=13)19285ND-428

Mouse SamplesMean (pg/mL)Range (pg/mLStandard Devation (pg/mL)
Serum (n=8)19778.1-35293.1
EDTA plasma (n=9)254136-47184.2
Heparin plasma (n=7)276210-34242.9

Rat SamplesMean (pg/mL)Range pg/mL)Standard Deviation (pg/mL)
Serum (n=8)306109-1466469
EDTA plasma (n=8)21497.7-31263.9
Heparin plasma (n=7)276210-34242.9

Cell Culture Supernates:
Notw: Cell culture supernates were not corrected for the presence of fetal bovine serum.

IMR-90 human fetal lung fibroblasts were cultured in MEM with 10% fetal bovine serum until confluent. An aliquot was removed, assayed for human/mouse/rat Activin A, and measured 5608 pg/mL.

WS-1 human fetal skin fibroblasts were cultured in MEM with 10% fetal bovine serum, NEAA, and 2 mM L-glutamine until confluent. Cells were then stimulated for an additional 24 hours with 100 ng/mL LPS, 10 ng/mL recombinant human IL-1 beta, or 10 ng/mL recombinant human TNF-alpha. Aliquots were removed and assayed for levels of human/mouse/rat Activin A.

StimulantDay 1 (pg/mL)
LPS8489
IL-1 beta 21,033
TNF-alpha 21,098

CMT-93 mouse rectal carcinoma cells were cultured in MEM with 10% fetal bovine serum, 2 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin sulfate until confluent. An aliquot was removed, assayed for human/mouse/rat Activin A, and measured 655 pg/mL. 

Product Summary

The Quantikine Human/Mouse/Rat Activin A Immunoassay is a 5.0 hour solid-phase ELISA designed to measure Activin A in human, mouse, or rat cell culture supernates, serum, plasma, and saliva. It contains CHO cell-expressed recombinant human/mouse/rat Activin A and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human/mouse/rat Activin A showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally expressed Activin A.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 101 295 498 106 308 529
Standard Deviation 4.2 12.5 21.9 8.4 15.5 24.8
CV% 4.2 4.2 4.4 7.9 5 4.7

Recovery

The recovery of human Activin A spiked to three different levels throughout the range of the assay was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 105 93-114
EDTA Plasma (n=4) 110 95-115
Heparin Plasma (n=4) 107 99-113
Serum (n=4) 109 100-115

Linearity

To assess the linearity of the assay, human samples containing and/or spiked with high concentrations of Activin A were diluted with the Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human/Mouse/Rat Activin A ELISA Linearity

Scientific Data

N/A Human/Mouse/Rat Activin A ELISA Standard Curve View Larger

Human/Mouse/Rat Activin A ELISA Standard Curve

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: Activin A

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.

Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins: Activin A (beta A - beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha - beta A) and Inhibin B (alpha - beta B).

Entrez Gene IDs:
3624 (Human); 16323 (Mouse); 29200 (Rat)
Alternate Names:
Activin A; activin AB alpha polypeptide; Activin beta-A chain; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; inhibin beta A chain; inhibin beta A subunit; Inhibin, beta-1
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Citations for Human/Mouse/Rat Activin A Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

61 Citations: Showing 1 - 10
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  1. Activin A levels are raised during human tuberculosis and blockade of the activin signaling axis influences murine responses to M. tuberculosis infection
    Authors: Nieuwenhuizen, NE;Nouailles, G;Sutherland, JS;Zyla, J;Pasternack, AH;Heyckendorf, J;Frye, BC;Höhne, K;Zedler, U;Bandermann, S;Abu Abed, U;Brinkmann, V;Gutbier, B;Witzenrath, M;Suttorp, N;Zissel, G;Lange, C;Ritvos, O;Kaufmann, SHE;CAPNETZ Study group, ;DZIF TB study group, ;
    mBio
    Species: Human, Mouse
    Sample Types: BALF, Serum
  2. Calorie restriction reduces biomarkers of cellular senescence in humans
    Authors: Aversa, Z;White, TA;Heeren, AA;Hulshizer, CA;Saul, D;Zhang, X;Molina, AJA;Redman, LM;Martin, CK;Racette, SB;Huffman, KM;Bhapkar, M;Khosla, S;Das, SK;Fielding, RA;Atkinson, EJ;LeBrasseur, NK;
    Aging cell
    Species: Human
    Sample Types: Plasma
  3. Biomarkers of cellular senescence and risk of death in humans
    Authors: St Sauver, JL;Weston, SA;Atkinson, EJ;Mc Gree, ME;Mielke, MM;White, TA;Heeren, AA;Olson, JE;Rocca, WA;Palmer, AK;Cummings, SR;Fielding, RA;Bielinski, SJ;LeBrasseur, NK;
    Aging cell
    Species: Human
    Sample Types: Plasma
  4. Immune Markers, Blood Pressure Severity, and Cardiac Remodeling 1 to 2?Years After Hypertensive Disorders of Pregnancy
    Authors: Koczo, A;Hauspurg, A;Countouris, ME;Berlacher, KL;Özbay, B;Hanley-Yanez, K;Catov, J;
    Journal of the American Heart Association
    Species: Human
    Sample Types: Serum
  5. AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva
    Authors: Yang, YS;Lin, C;Ma, H;Xie, J;Kaplan, FS;Gao, G;Shim, JH;
    Biomolecules
    Species: Transgenic Mouse, Human
    Sample Types: Cell Culture Supernates, Tissue Homogenates
  6. Acoustic Atomization-Induced Pumping Based on a Vibrating Sharp-Tip Capillary
    Authors: Mendis, BL;He, Z;Li, X;Wang, J;Li, C;Li, P;
    Micromachines
    Species: N/A
    Sample Types: Recombinant Protein
  7. Biomarkers of cellular senescence in idiopathic pulmonary fibrosis
    Authors: Z Aversa, EJ Atkinson, EM Carmona, TA White, AA Heeren, SK Jachim, X Zhang, SR Cummings, SE Chiarella, AH Limper, NK LeBrasseur
    Respiratory Research, 2023-04-07;24(1):101.
    Species: Human
    Sample Types: Plasma
  8. Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
    Authors: AL Queiroz, E Dantas, S Ramsamooj, A Murthy, M Ahmed, ERM Zunica, RJ Liang, J Murphy, CD Holman, CJ Bare, G Ghahramani, Z Wu, DE Cohen, JP Kirwan, LC Cantley, CL Axelrod, MD Goncalves
    Nature Communications, 2022-08-08;13(1):4633.
    Species: Human
    Sample Types: Serum
  9. The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients
    Authors: M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass
    Molecular and Cellular Biology, 2021-11-01;0(0):MCB0046721.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors
    Authors: KA Cho, DW Choi, YH Kim, J Kim, KH Ryu, SY Woo
    Cells, 2021-08-23;10(8):.
    Species: Mouse
    Sample Types: Serum
  11. Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model
    Authors: D Mori, S Miyagawa, T Kido, H Hata, T Ueno, K Toda, T Kuratani, M Oota, K Kawai, H Kurata, H Nishida, Y Sawa
    Regenerative Therapy, 2021-07-09;18(0):182-190.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Role of stromal activin A in human pancreatic cancer and metastasis in mice
    Authors: G Mancinelli, C Torres, N Krett, J Bauer, K Castellano, R McKinney, D Dawson, G Guzman, R Hwang, S Grimaldo, P Grippo, B Jung
    Scientific Reports, 2021-04-12;11(1):7986.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates, Plasma
  13. Carfilzomib Improves Bone Metabolism in Patients with Advanced Relapsed/Refractory Multiple Myeloma: Results of the CarMMa Study
    Authors: E Terpos, I Ntanasis-S, E Katodritou, MC Kyrtsonis, V Douka, E Spanoudaki, A Papatheodo, E Eleutherak, N Kanellias, M Gavriatopo, P Makras, E Kastritis, MA Dimopoulos
    Cancers, 2021-03-12;13(6):.
    Species: Human
    Sample Types: Serum
  14. miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin
    Authors: N Mehta, R Li, D Zhang, A Soomro, J He, I Zhang, M MacDonald, B Gao, JC Krepinsky
    Scientific Reports, 2021-01-08;11(1):88.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. Metallothionein-1G suppresses pancreatic cancer cell stemness by limiting activin A secretion via NF-&kappaB inhibition
    Authors: K Li, Z Zhang, Y Mei, Q Yang, S Qiao, C Ni, Y Yao, X Li, M Li, D Wei, W Fu, X Guo, X Huang, H Yang
    Theranostics, 2021-01-01;11(7):3196-3212.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Neuroadaptations in the dorsal hippocampus underlie cocaine seeking during prolonged abstinence
    Authors: CT Werner, S Mitra, BD Auerbach, ZJ Wang, JA Martin, AF Stewart, PH Gobira, M Iida, C An, MM Cobb, A Caccamise, RJ Salvi, RL Neve, AM Gancarz, DM Dietz
    Proc Natl Acad Sci U S A, 2020-10-05;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  17. Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner
    Authors: B Soler Pala, C Nieto, P Fajardo, A González d, N Andrés, Á Dominguez-, P Lucas, A Cuenda, JM Rodríguez-, C Martínez-A, R Villares, ÁL Corbí, M Mellado
    J. Immunol., 2020-06-26;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  18. The senescence-associated secretome as an indicator of age and medical risk
    Authors: MJ Schafer, X Zhang, A Kumar, EJ Atkinson, Y Zhu, S Jachim, DL Mazula, AK Brown, M Berning, Z Aversa, B Kotajarvi, CJ Bruce, KL Greason, RM Suri, RP Tracy, SR Cummings, TA White, NK LeBrasseur
    JCI Insight, 2020-06-18;5(12):.
    Species: Human
    Sample Types: Plasma
  19. Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index
    Authors: AL Thomas, K Castellano, G Mancinelli, Y Xia, J Bauer, C Yazici, G Fantuzzi, RF Hwang, NL Krett, GI Papachrist, DC Whitcomb, B Jung
    Clin Transl Gastroenterol, 2020-05-01;11(5):e00152.
    Species: Mouse
    Sample Types: Plasma
  20. Hydroxychloroquine Mitigates the Production of 8-Isoprostane and Improves Vascular Dysfunction: Implications for Treating Preeclampsia
    Authors: RA Rahman, P Murthi, H Singh, S Gurungsing, B Leaw, JC Mockler, R Lim, EM Wallace
    Int J Mol Sci, 2020-04-03;21(7):.
    Species: Human
    Sample Types: Placenta
  21. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia
    Authors: C Pan, N Jaiswal Ag, Y Zulia, S Singh, K Sha, JL Mohler, KH Eng, J Chakkalaka, JJ Krolewski, KL Nastiuk
    JCI Insight, 2020-03-26;0(0):.
    Species: Mouse
    Sample Types: Serum
  22. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia
    Authors: A Oppezzo, J Bourseguin, E Renaud, P Pawlikowsk, F Rosselli
    J. Clin. Invest., 2020-03-02;0(0):.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates
  23. Serum Activin A Levels and Renal Outcomes After Coronary Angiography
    Authors: YL Tsai, RH Chou, YW Lu, CT Liu, PH Huang, SJ Lin
    Sci Rep, 2020-02-25;10(1):3365.
    Species: Human
    Sample Types: Serum
  24. Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling
    Authors: J Bauer, MAB Emon, JJ Staudacher, AL Thomas, J Zessner-Sp, G Mancinelli, N Krett, MT Saif, B Jung
    Sci Rep, 2020-01-09;10(1):50.
    Species: Human
    Sample Types: Cell Culture Supernates
  25. Urinary Activin A is a novel biomarker reflecting renal inflammation and tubular damage in ANCA-associated vasculitis
    Authors: Y Takei, S Takahashi, M Nakasatomi, T Sakairi, H Ikeuchi, Y Kaneko, K Hiromura, Y Nojima, A Maeshima
    PLoS ONE, 2019-10-15;14(10):e0223703.
    Species: Human
    Sample Types: Serum
  26. Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging
    Authors: A Lepletier, ML Hun, MV Hammett, K Wong, H Naeem, M Hedger, K Loveland, AP Chidgey
    Cell Rep, 2019-06-25;27(13):3887-3901.e4.
    Species: Mouse
    Sample Types: Serum
  27. Diagnostic and prognostic values of serum activin-a levels in patients with acute respiratory distress syndrome
    Authors: JM Kim, JK Lee, SM Choi, J Lee, YS Park, CH Lee, JJ Yim, CG Yoo, YW Kim, SK Han, SM Lee
    BMC Pulm Med, 2019-06-25;19(1):115.
    Species: Human
    Sample Types: Serum
  28. Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells
    Authors: CN Tsai, CL Tsai, JS Yi, HK Kao, Y Huang, CI Wang, YS Lee, KP Chang
    Sci Rep, 2019-03-26;9(1):5197.
    Species: Human
    Sample Types: Cell Culture Supernates
  29. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms
    Authors: K Fujiki, H Inamura, T Sugaya, M Matsuoka
    Cell Death Differ., 2019-02-25;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia
    Authors: P Rentsch, S Stayte, GP Morris, B Vissel
    BMC Neurosci, 2019-02-13;20(1):5.
    Species: Mouse
    Sample Types: Tissue Homogenates
  31. Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
    Authors: JN Justice, AM Nambiar, T Tchkonia, NK LeBrasseur, R Pascual, SK Hashmi, L Prata, MM Masternak, SB Kritchevsk, N Musi, JL Kirkland
    EBioMedicine, 2019-01-05;0(0):.
    Species: Human
    Sample Types: Serum
  32. NF-?B/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification
    Authors: E Barruet, BM Morales, CJ Cain, AN Ton, KL Wentworth, TV Chan, TA Moody, MC Haks, TH Ottenhoff, J Hellman, MC Nakamura, EC Hsiao
    JCI Insight, 2018-11-15;3(22):.
    Species: Human
    Sample Types: Serum
  33. Activin subfamily peptides predict chronological age in humans
    Authors: LV Barrios-Si, M Parnell, ZB Shinwari, GA Chaudhary, T Xenofontos, A van Bekhov, S McArthur, BT Elliott
    Physiol Rep, 2018-09-01;6(17):e13823.
    Species: Human
    Sample Types: Plasma
  34. Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells
    Authors: CFD Rodrigues, E Serrano, MI Patrício, MM Val, P Albuquerqu, J Fonseca, CMF Gomes, AJ Abrunhosa, A Paiva, L Carvalho, MF Botelho, L Almeida, IM Carreira, MC Alpoim
    Sci Rep, 2018-08-01;8(1):11573.
    Species: Human
    Sample Types: Cell Culture Supernates
  35. Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells
    Authors: M Shoji, H Minato, S Ogaki, M Seki, Y Suzuki, S Kume, T Kuzuhara
    PLoS ONE, 2018-07-26;13(7):e0201239.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  36. Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats
    Authors: J Hu, X Wang, YH Tang, YG Shan, Q Zou, ZQ Wang, CX Huang
    Mol Med Rep, 2018-01-25;17(4):5074-5080.
    Species: Rat
    Sample Types: Serum
  37. ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass
    Authors: R Barreto, Y Kitase, T Matsumoto, F Pin, KC Colston, KE Couch, TM O'Connell, ME Couch, LF Bonewald, A Bonetto
    Sci Rep, 2017-10-31;7(1):14470.
    Species: Mouse
    Sample Types: Plasma
  38. Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target.
    Authors: Jonas J Staudacher, Cemal Yazici, Timothy Carroll, Jessica Bauer, Jingbo Pang, Nancy Krett, Yinglin Xia, Annette Wilson, Georgios Papachris, Andrea Dirmeier, Claudia Kunst, David C Whitcomb, Giamila Fantuzzi, Barbara Jung
    Scientific Reports, 2017-10-06;0(0):2045-2322.
    Species: Human, Mouse
    Sample Types: Serum
    Applications: ELISA Capture
  39. Inhibin-A and Decorin Secreted by Human Adult Renal Stem/Progenitor Cells Through the TLR2 Engagement Induce Renal Tubular Cell Regeneration
    Authors: F Sallustio, C Curci, A Aloisi, CC Toma, E Marulli, G Serino, SN Cox, G De Palma, A Stasi, C Divella, R Rinaldi, FP Schena
    Sci Rep, 2017-08-15;7(1):8225.
    Species: Human
    Sample Types: Whole Cells
  40. Vitamin D supplementation lowers thrombospondin-1 levels and blood pressure in healthy adults
    Authors: AT Amaraseker, B Assadi-Kha, S Liu, M Black, G Dymmott, NM Rogers, AL Sverdlov, JD Horowitz, DTM Ngo
    PLoS ONE, 2017-05-10;12(5):e0174435.
    Species: Human
    Sample Types: Plasma
  41. Activin A more prominently regulates muscle mass in primates than does GDF8
    Authors: E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada
    Nat Commun, 2017-04-28;8(0):15153.
    Species: Human, Mouse, Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Rat
    Sample Types: Serum
  42. Activin A is increased in the nucleus accumbens following a cocaine binge
    Authors: ZJ Wang, JA Martin, AM Gancarz, DN Adank, FJ Sim, DM Dietz
    Sci Rep, 2017-03-08;7(0):43658.
    Species: Rat
    Sample Types: Tissue Homogenates
  43. Immunoselected STRO-3(+) mesenchymal precursor cells reduce inflammation and improve clinical outcomes in a large animal model of monoarthritis
    Authors: A Abdalmula, LM Dooley, C Kaufman, EA Washington, JV House, BA Blacklaws, P Ghosh, S Itescu, SR Bailey, WG Kimpton
    Stem Cell Res Ther, 2017-02-07;8(1):22.
    Species: Ovine
    Sample Types: Plasma
  44. Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo
    Authors: S Stayte, P Rentsch, AR Tr”scher, M Bamberger, KM Li, B Vissel
    PLoS ONE, 2017-01-25;12(1):e0167211.
    Species: Mouse
    Sample Types: Tissue Homogenates
  45. A Key Role for Inhibins in Dendritic Cell Maturation and Function
    PLoS ONE, 2016-12-09;11(12):e0167813.
    Species: Mouse
    Sample Types: Cell Culture Supernates
  46. Involvement of Infiltrating Macrophage-derived Activin A in the Progression of Renal Damage in MRL-lpr Mice
    Authors: Yoshihisa Nojima
    Am. J. Physiol. Renal Physiol., 2016-11-23;0(0):ajprenal.0019.
    Species: Mouse
    Sample Types: Urine
  47. Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice
    Authors: Edward O List
    Nutr Healthy Aging, 2016-10-27;4(1):95-99.
    Species: Mouse
    Sample Types: Plasma
  48. Predicting first trimester pregnancy outcome: derivation of a multiple marker test
    Authors: S Senapati, MD Sammel, SF Butts, P Takacs, K Chung, KT Barnhart
    Fertil. Steril., 2016-10-26;106(7):1725-1732.e3.
    Species: Human
    Sample Types: Serum
  49. Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study
    Authors: Laura Hildebrand
    J Trace Elem Med Biol, 2016-10-04;39(0):186-192.
    Species: Human
    Sample Types: Serum
  50. Late acute graft versus host disease: a prospective analysis of clinical outcomes and circulating angiogenic factors
    Blood, 2016-09-13;0(0):.
    Species: Human
    Sample Types: Plasma
  51. Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes
    Authors: Tonia L Vincent
    Arthritis & rheumatology (Hoboken, N.J.), 2016-09-01;68(9):2129-40.
    Species: Human
    Sample Types: Plasma
  52. Activin A programs the differentiation of human TFH cells
    Nat Immunol, 2016-07-04;17(8):976-84.
    Species: Human
    Sample Types: Cell Culture Supernates
  53. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-beta.
    Authors: Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El-Sayed K, Ehnert S, Nussler A, Fandrich F, Gieseler F
    PLoS ONE, 2015-02-23;10(2):e0118097.
    Species: Human
    Sample Types: Cell Culture Supernates
  54. The differential anti-tumour effects of zoledronic acid in breast cancer - evidence for a role of the activin signaling pathway.
    Authors: Wilson C, Ottewell P, Coleman R, Holen I
    BMC Cancer, 2015-02-14;15(0):55.
    Species: Human
    Sample Types: Cell Culture Supernates
  55. Serum activin A and follistatin levels in gestational diabetes and the association of the Activin A-Follistatin system with anthropometric parameters in offspring.
    Authors: Naf S, Escote X, Ballesteros M, Yanez R, Simon-Muela I, Gil P, Albaiges G, Vendrell J, Megia A
    PLoS ONE, 2014-04-24;9(4):e92175.
    Species: Human
    Sample Types: Serum
  56. Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
    Authors: Chen L, Zhang W, Liang H, Zhou Q, Ding Z, Yang H, Liu W, Wu Y, Man Q, Zhang B, Chen X
    Cell Commun Signal, 2014-03-17;12(0):18.
    Species: Rat
    Sample Types: Cell Culture Supernates
  57. PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism.
    Authors: Li C, Peart N, Xuan Z, Lewis D, Xia Y, Jin J
    Cell Signal, 2014-03-15;26(7):1369-78.
    Species: Human
    Sample Types: Cell Culture Supernates
  58. Activin A is associated with impaired myocardial glucose metabolism and left ventricular remodeling in patients with uncomplicated type 2 diabetes.
    Authors: Chen W, Greulich S, van der Meer R, Rijzewijk L, Lamb H, de Roos A, Smit J, Romijn J, Ruige J, Lammertsma A, Lubberink M, Diamant M, Ouwens D
    Cardiovasc Diabetol, 2013-10-17;12(1):150.
    Species: Human
    Sample Types: Plasma
  59. An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice.
    Authors: Pitetti J, Calvel P, Zimmermann C, Conne B, Papaioannou M, Aubry F, Cederroth C, Urner F, Fumel B, Crausaz M, Docquier M, Herrera P, Pralong F, Germond M, Guillou F, Jegou B, Nef S
    Mol Endocrinol, 2013-03-21;27(5):814-27.
    Species: Mouse
    Sample Types: Serum
  60. Mechanisms inducing low bone density in duchenne muscular dystrophy in mice and humans.
    Authors: Rufo A, Del Fattore A, Capulli M, Carvello F, De Pasquale L, Ferrari S, Pierroz D, Morandi L, De Simone M, Rucci N, Bertini E, Bianchi ML, De Benedetti F, Teti A
    J. Bone Miner. Res., 2011-08-01;26(8):1891-903.
    Species: Human
    Sample Types: Serum
  61. Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers.
    Authors: Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabeu C, Vega MA, Corbi AL
    Blood, 2011-03-09;117(19):5092-101.
    Species: Mouse
    Sample Types: Cell Culture Supernates

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Average Rating: 4.7 (Based on 10 Reviews)

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Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Anonymous on 07/27/2022
Sample Tested: Mouse serum samples
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Anonymous on 06/30/2022
Sample Tested: Serum
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By APK Inmunometabolismo on 11/06/2020
Sample Tested: Cell culture supernatant
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Anonymous on 11/04/2020
Sample Tested: Cell culture supernatant
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By bing wu on 06/26/2020
Sample Tested: Serum-free Cell Culture Media,T cells
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Anonymous on 03/14/2019
Sample Tested: Serum and Plasma
Human/Mouse/Rat Activin A Quantikine ELISA Kit DAC00B
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Corina White on 05/16/2017
Sample Tested: Recombinant protein
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Anonymous on 05/03/2017
Sample Tested: Serum
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Elizabeth Belonga on 04/24/2017
Sample Tested: Serum
Human/Mouse/Rat Activin A Quantikine ELISA Kit
By Corina White on 04/21/2017
Sample Tested: Recombinant protein