Human/Mouse IL-1ra/IL-1F3 Antibody Summary
Arg27-Gln178
Accession # P25085
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-1ra/IL-1F3
IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.
Product Datasheets
Citations for Human/Mouse IL-1ra/IL-1F3 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke
Authors: BH Clausen, M Wirenfeldt, SS Høgedal, LH Frich, HH Nielsen, HD Schrøder, K Østergaard, B Finsen, BW Kristensen, KL Lambertsen
Acta Neuropathol Commun, 2020-06-05;8(1):81.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium.
Authors: Murtuza B, Suzuki K, Bou-Gharios G, Beauchamp JR, Smolenski RT, Partridge TA, Yacoub MH
Proc. Natl. Acad. Sci. U.S.A., 2004-03-12;101(12):4216-21.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
FcgammaR expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA)
Authors: Arjen B Blom, Peter L van Lent, Hanneke van Vuuren, Astrid E Holthuysen, Cor Jacobs, Leo B van de Putte et al.
Arthritis Res
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