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Human MMP-10 Antibody

Catalog #: MAB910
9 Citations 2 Reviews Datasheet
Catalog # Availability Size / Price Qty
MAB910-SP
MAB910-500
MAB910-100
MMP‑10 in Human Colon Cancer Tissue.
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Product Details
Citations (9)
FAQs
Supplemental Products
Reviews (2)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human MMP-10 Antibody Summary

Species Reactivity
Human
Specificity
Detects human MMP-10 in Western blots. Does not cross-react with recombinant human MMP-1, -2, -3, -7, -8, -9, -12, or -13.
Source
Monoclonal Mouse IgG1 Clone # 110304
Purification
Protein A or G purified from ascites
Immunogen
Mouse myeloma cell line NS0-derived recombinant human MMP-10
Tyr18-Cys476
Accession # P09238
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human MMP‑10 Western Blot Standard (Catalog # WBC026)
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry MMP‑10 antibody in Human Colon Cancer Tissue by Immunohistochemistry (IHC-P). View Larger

MMP‑10 in Human Colon Cancer Tissue. MMP‑10 was detected in immersion fixed paraffin-embedded sections of human colon cancer using Human MMP‑10 Monoclonal Antibody (Catalog # MAB910) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: MMP-10

Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-10 (stromelysin 2) degrades a broad range of substrates including gelatin, collagen types III, IV and V, fibronectin, aggrecan, and pig cartilage proteoglycan. MMP-10 can activate other MMPs such as MMP-1 and MMP-8. MMP-10 is expressed in keratinocytes, T cells, menstrual endometrium, and a few tumor samples. Structurally, MMP-10 may be divided into four distinct domains: a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site; a short linker region, and a carboxyl terminal hemopexin-like domain.

Long Name
Matrix Metalloproteinase 10
Entrez Gene IDs
4319 (Human)
Alternate Names
EC 3.4.24; EC 3.4.24.22; matrix metallopeptidase 10 (stromelysin 2); matrix metalloprotease 10; matrix metalloproteinase 10 (stromelysin 2); Matrix metalloproteinase-10; MMP10; MMP-10; SL-2; STMY2stromelysin-2; Stromelysin 2; transin 2; transin-2

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Citations for Human MMP-10 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation
    Authors: Li, L;Jiao, L;Feng, D;Yuan, Y;Yang, X;Li, J;Jiang, D;Chen, H;Meng, Q;Chen, R;Fang, B;Zou, X;Luo, Z;Ye, X;Hong, Y;Liu, C;Li, C;
    Nature communications
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. Higher Content but Not Activity of Stromelysin-2 (MMP-10) in Comparison to Stromelysin-1 (MMP-3) in Human Renal Carcinoma
    Authors: J Kudelski, G M?ynarczyk, M Gudowska-S, B Mroczko, B Darewicz, M Bruczko-Go, L Romanowicz
    International Journal of Environmental Research and Public Health, 2022-10-02;19(19):.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  3. Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma
    Authors: J Kudelski, G M?ynarczyk, M Gudowska-S, B Mroczko, B Darewicz, M Bruczko-Go, K Sobolewski, L Romanowicz
    Journal of Clinical Medicine, 2021-08-19;10(16):.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  4. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis
    Authors: Jameson T. Crowley, Klemen Strle, Elise E. Drouin, Annalisa Pianta, Sheila L. Arvikar, Qi Wang et al.
    Journal of Autoimmunity
  5. MMP-1 and Pro-MMP-10 as potential urinary pharmacodynamic biomarkers of FGFR3-targeted therapy in patients with bladder cancer.
    Authors: Du X, Lin B, Wang Q, Li H, Ingalla E, Tien J, Rooney I, Ashkenazi A, Penuel E, Qing J
    Clin Cancer Res, 2014-10-17;20(24):6324-35.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  6. Matrix metalloproteinase activity in pediatric acute lung injury.
    Authors: Kong MY, Gaggar A, Li Y
    Int J Med Sci, 2008-12-16;6(1):9-17.
    Species: Human
    Sample Types: Tissue Secretion
    Applications: Western Blot
  7. AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor.
    Authors: Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K
    J. Invest. Dermatol., 2008-11-20;129(5):1140-8.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
    Authors: Puram Sidharth V, Tirosh Itay, Parikh Anuraag S et al.
    Cell
  9. Modulation of proteoglycan receptor PTP? enhances MMP-2 activity to promote recovery from multiple sclerosis
    Authors: F Luo, AP Tran, L Xin, C Sanapala, BT Lang, J Silver, Y Yang
    Nat Commun, 2018-10-08;9(1):4126.

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Reviews for Human MMP-10 Antibody

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Human MMP-10 Antibody
By Anonymous on 02/13/2022
Application: IHC Sample Tested: Colon cancer tissue Species: Human
Immunohistochemistry Human MMP-10 Antibody MAB910
Human MMP-10 Antibody
By avinash waghray on 04/25/2018
Application: Immunocytochemistry/Immunofluorescence Sample Tested: human lung normal Species: Human
Immunocytochemistry/Immunofluorescence Human MMP-10 Antibody MAB910