Human Mer APC-conjugated Antibody Summary
Met1-Ala499
Accession # AAB60430
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Mer in HepG2 Human Cell Line by Flow Cytometry. HepG2 human hepatocellular carcinoma cell line was stained with Mouse Anti-Human Mer APC-conjugated Monoclonal Antibody (Catalog # FAB8912A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of Mer in U937 Human Cell Line by Flow Cytometry. U937 human histiocytic lymphoma cell line was stained with Mouse Anti-Human Mer APC-conjugated Monoclonal Antibody (Catalog # FAB8912A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: Mer
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken c-Eyk) constitute a receptor tyrosine kinase subfamily. The extracellular domains of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. These receptors bind the vitamin K-dependent protein growth-arrest-specific gene 6 (Gas6) which is structurally related to the anticoagulation factor protein S. Binding of Gas6 induces receptor autophosphorylation and downstream signaling pathways that can lead to cell proliferation, migration or the prevention of apoptosis. Recent studies suggest that this family of tyrosine kinase receptors may be involved in hematopoiesis, embryonic development, tumorigenesis and regulation of testicular functions.
- Nagata, K. et al. (1996) J. Biol. Chem. 22:30022.
- Crosier, K.E. and P.S Crosier (1997) Pathology 29:131.
Product Datasheets
Citations for Human Mer APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
11
Citations: Showing 1 - 10
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Regulation of Mertk Surface Expression via ADAM17 and ?-Secretase Proteolytic Processing
Authors: Lahey, KC;Varsanyi, C;Wang, Z;Aquib, A;Gadiyar, V;Rodrigues, AA;Pulica, R;Desind, S;Davra, V;Calianese, DC;Liu, D;Cho, JH;Kotenko, SV;De Lorenzo, MS;Birge, RB;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
Authors: Oltin-Tiberiu Pop, Anne Geng, Emilio Flint, Arjuna Singanayagam, Caner Ercan, Lucia Possamai et al.
Cellular and Molecular Gastroenterology and Hepatology
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Anti-inflammatory clearance of amyloid-beta by a chimeric Gas6 fusion protein
Authors: H Jung, SY Lee, S Lim, HR Choi, Y Choi, M Kim, S Kim, Y Lee, KH Han, WS Chung, CH Kim
Nature Medicine, 2022-08-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causes
Authors: FM Trovato, S Mujib, E Jerome, A Cavazza, P Morgan, J Smith, MT Depante, K O'Reilly, J Luxton, T Mare, S Napoli, MJ McPhail
Heliyon, 2022-06-24;8(6):e09733.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cladribine Treatment for MS Preserves the Differentiative Capacity of Subsequently Generated Monocytes, Whereas Its Administration In Vitro Acutely Influences Monocyte Differentiation but Not Microglial Activation
Authors: Tiago Medeiros-Furquim, Sinan Ayoub, Laura J. Johnson, Andrea Aprico, Eze Nwoke, Michele D. Binder et al.
Frontiers in Immunology
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A Heterotypic Tridimensional Model to Study the Interaction of Macrophages and Glioblastoma In Vitro
Authors: MJ Gattas, IG Estecho, MA Lago Huvel, AE Errasti, EA Carrera Si, M Simian
International Journal of Molecular Sciences, 2021-05-12;22(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Pro-inflammatory monocyte profile in patients with major depressive disorder and suicide behaviour and how ketamine induces anti-inflammatory M2 macrophages by NMDAR and mTOR
Authors: W Nowak, LN Grendas, LM Sanmarco, IG Estecho, ÁR Arena, N Eberhardt, DE Rodante, MP Aoki, FM Daray, EA Carrera Si, AE Errasti
EBioMedicine, 2019-11-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice
Authors: A Carestia, HA Mena, CM Olexen, JM Ortiz Wilc, S Negrotto, AE Errasti, RM Gómez, CN Jenne, EA Carrera Si, M Schattner
Cell Rep, 2019-07-23;28(4):896-908.e5.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors
Authors: FJ Zapatero-B, E Dietzel, O Dolnik, K Döhner, R Costa, B Hertel, B Veselkova, J Kirui, A Klintworth, MP Manns, S Pöhlmann, T Pietschman, T Krey, S Ciesek, G Gerold, B Sodeik, S Becker, T von Hahn
Viruses, 2019-03-19;11(3):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
Authors: E Triantafyl, OT Pop, LA Possamai, A Wilhelm, E Liaskou, A Singanayag, C Bernsmeier, W Khamri, G Petts, R Dargue, SP Davies, J Tickle, M Yuksel, VC Patel, RD Abeles, Z Stamataki, SM Curbishley, Y Ma, ID Wilson, M Coen, KJ Woollard, A Quaglia, J Wendon, MR Thursz, DH Adams, CJ Weston, CG Antoniades
Gut, 2017-04-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TAM receptor-dependent regulation of SOCS3 and MAPKs contributes to proinflammatory cytokine downregulation following chronic NOD2 stimulation of human macrophages.
Authors: Zheng S, Hedl M, Abraham C
J Immunol, 2015-01-07;194(4):1928-37.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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