Human LAP (TGF-beta 1) APC-conjugated Antibody Summary
Leu30-Arg278 (Cys33Ser)
Accession # P01137
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) APC-conjugated Monoclonal Antibody (Catalog # FAB2463A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: LAP (TGF-beta 1)
The TGF‑ beta family includes several related proteins (70‑80% sequence homology) from mammalian, avian, or Xenopus systems that are now designated TGF‑ beta 1, TGF‑ beta 2, TGF‑ beta 1.2, TGF‑ beta 3, TGF‑ beta 4, and TGF‑ beta 5. These proteins are secreted by cells in the form of an inactive complex, referred to as latent TGF-beta, that consists of TGF‑ beta associated non-covalently with a Latency-associated peptide (LAP). These two proteins are synthesized as a single pro-peptide that is cleaved in a post Golgi compartment prior to secretion. Different TGF‑ beta family members are naturally associated with their own distinct LAPs.
Product Datasheets
Citations for Human LAP (TGF-beta 1) APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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GPI-80 as a Useful Index for Myeloid Cell Heterogeneity and a Potential Prognostic Biomarker for Metastatic Renal Cell Carcinoma
Authors: T Kato, Y Takeda, H Ito, Y Kurota, A Yamagishi, T Sakurai, S Naito, A Araki, H Nara, H Asao, N Tsuchiya
Tohoku J. Exp. Med., 2019-11-01;249(3):203-212.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor beta1 (TGF-beta1) Production in Human Regulatory T Cells.
Authors: Huygens C, Lienart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie P, Lucas S
J Biol Chem, 2015-06-30;290(33):20105-16.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
Authors: Zhu Z, Meng K, Zhong Y, Qi L, Mao X, Yu K, Zhang W, Zhu P, Ren Z, Wu B, Ji Q, Wang X, Zeng Q
PLoS ONE, 2014-02-18;9(2):e88775.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Authors: Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
J. Immunol., 2012-01-16;188(4):2001-13.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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How do you isolate human platelets for flow cytometry, using Human LAP (TGF-beta 1) Antibody, Catalog # MAB2463, and its conjugates?
We obtain the platelets from blood plasma by collection the top layer after spinning down whole blood. We proceed with a normal surface stain protocol; no special buffers are required.
Reviews for Human LAP (TGF-beta 1) APC-conjugated Antibody
Average Rating: 4 (Based on 1 Review)
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