Human Integrin beta 6 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB41551V Datasheet

Catalog #	Availability	Size / Price	Qty
FAB41551V-100UG

All Integrin beta 6 Antibodies

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Human Integrin beta 6 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Integrin beta 6 in direct ELISAs and Western blots. In Western blots (under reducing conditions), 40% cross‑reactivity with recombinant human (rh) Integrin beta 2 is observed and no cross-reactivity with rhIntegrin beta 1, 3, 5,

Source

Monoclonal Mouse IgG2b Clone # 437216

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Integrin Î²6
Gly22-Asn707
Accession # P18564

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Integrin beta 6

Integrin beta 6 (ITG beta 6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha V and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta 6 is a type I transmembrane glycoprotein that is 767 aa in length. It contains a 688 aa extracellular domain (ECD) (aa 22‑709) that incorporates a 241 aa VWF-A domain. Over aa 22‑707, human integrin beta 6 ECD shares 90% and 93% aa sequence identity with mouse and porcine integrin beta 6 ECD, respectively.

Entrez Gene IDs

3694 (Human); 16420 (Mouse); 311061 (Rat); 102122296 (Cynomolgus Monkey)

Alternate Names

Integrin beta 6; integrin beta-6; integrin, beta 6; ITGB6

Product Datasheets

Product Datasheet

Related Research Areas

FAQs

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