Human Integrin  alpha 6/CD49f Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Integrin alpha 6/CD49f

Integrin alpha 6 (also VLA-6, CD49F and ITA6) is a 130‑150 kDa member of the integrin alpha chain family of molecules. Mature Integrin  alpha 6 is a 1107 amino acid (aa) type I transmembrane glycoprotein that contains a 1027 aa extracellular region and a 93 aa cytoplasmic tail The ECD is cleaved to generate a disulfide-linked dimer that shows a 125 kDa heavy chain (aa 24‑938), and a 30‑31 kDa membrane-bound light chain (aa 942‑1130). Integrin alpha 6 forms a nondisulfide-linked heterodimeric complex with both integrin beta 1 and beta 4. Each complex serves as a receptor for laminin. Splice variants exist that show either a deletion of aa 215‑258 or a deletion of aa 260‑298, possibly accompanied by a 29 aa substitution for aa 1084‑1130. Over aa 93‑148 and 518‑574, human Integrin alpha 6 shares 89% aa identity with mouse Integrin alpha 6.

Product Datasheets

Related Research Areas

• Actin Stress Fibers and Focal Adhesions During EMT
• Acute Lymphoblastic Leukemia
• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on VSMC
• Adhesive Interactions in Allergy and Asthma
• Alpha Granule Membrane Proteins
• Cancer Stem Cell Markers
• Embryonic and Induced Pluripotent Stem Cell Markers
• Epithelial Cell Polarity
• Hematopoietic Stem Cell Markers
• Integrins and Associated Molecules
• Microglia Activation
• Platelet Adhesion Molecules
• Skin Stem Cell Markers