Human IL-17 QuicKit Control Group 272

Human IL-17 QuicKit Control Group 272 Summary

Specifications

Product Datasheets

Background: IL-17/IL-17A

The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.

Related Research Areas

• B Cell Chemotaxis, Migration, and Adhesion
• Cytokines and Receptors in Tfh Cell Differentiation and Function
• gamma delta T Cells
• Helper T (Th) Cells
• IL-17 Family
• LTi Cells
• Macrophage Activation Markers
• Microglia Activation Markers
• Molecules Secreted by VSMC
• Multiple Sclerosis and Myelin Related Molecules
• Natural Killer T (NKT) Cells
• NCR-ILC3
• Neuroinflammatory Factors
• Search Cytokine and Growth Factor Products
• T Cell Cytokine Signaling
• Th17 Cells