Human IL-1 RI Fluorescein-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IL‑1 RI in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Goat Anti-Human IL-1 RI Fluorescein-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB269F, filled histogram) or control antibody (Catalog # IC108F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-1 RI
Two distinct types of receptors that bind the pleiotropic cytokines IL-1 alpha and IL-1 beta have been described. The IL-1 receptor Type I is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence identity in their extracellular domains. The two receptor types do not heterodimerize into a receptor complex.
An IL-1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL-1 alpha or IL-1 beta but not IL-1ra, was identified (1). This Type I receptor complex appears to mediate all the known IL-1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.
Product Datasheets
Citations for Human IL-1 RI Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
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Tranilast Directly Targets NLRP3 to Protect Melanocytes From Keratinocyte-Derived IL-1 beta Under Oxidative Stress
Authors: Tongtian Zhuang, Shuli Li, Xiuli Yi, Sen Guo, Yinghan Wang, Jianru Chen et al.
Frontiers in Cell and Developmental Biology
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Ocular Fibroblast Diversity: Implications for Inflammation and Ocular Wound Healing
Authors: Xia Xi, David H. McMillan, Geniece M. Lehmann, Patricia J. Sime, Richard T. Libby, Krystel R. Huxlin et al.
Investigative Opthalmology & Visual Science
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Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis.
Authors: Mythilypriya Rajendran, Stephen Looney, Nagendra Singh, Mahmoud Elashiry, Mohamed M. Meghil, Ahmed R. El-Awady et al.
The Journal of Immunology
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Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells
Authors: Y Xu, M Twarog, N Li, A Banks, J Schustak, Y Bao, Q Huang, QG Medley
PLoS ONE, 2022-07-28;17(7):e0271656.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TNF-alpha and IL-1beta sensitize human MSC for IFN-gamma signalling and enhance neutrophil recruitment
Authors: A Hackel, A Aksamit, K Bruderek, S Lang, S Brandau
Eur. J. Immunol., 2020-09-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
Authors: M Bergström, M Müller, M Karlsson, H Scholz, NT Vethe, O Korsgren
Cell Transplant, 2019-09-12;0(0):9636897198724.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
Authors: Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, Nie W, Reszka-Blanco N, Wang F, Su L
J Clin Invest, 2015-08-24;125(9):3692-703.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
Authors: Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S
J Immunol, 2015-04-20;194(11):5139-49.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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