Home / IGF-I R/IGF1R / Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody

Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody

Catalog #: MAB11053-FAB2 Datasheet
Recombinant Monoclonal Antibody For Research Use Only
Catalog # Availability Size / Price Qty
MAB11053-FAB2-100
MAB11053-FAB2-SP
Detection of IGF-1 R/IGF1R in MCF‑7 Human Cell Line by Flow Cytometry.
2 Images
Product Details
FAQs
Supplemental Products
Reviews
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody Summary

Species Reactivity
Human
Specificity
Detects human IGF-1/IGF-1R in direct ELISAs.
Source
Recombinant Monoclonal Human IgG1 Clone # Hu14F2
Purification
Protein A or G purified from cell culture supernatant
Immunogen
Human IGF-1 R/IGF1R
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Flow Cytometry
0.25 µg/106 cells
MCF-7 human breast cancer cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry View Larger

Detection of IGF-1 R/IGF1R in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Human Anti-Human IGF-1 R/IGF1R (Teprotumumab) Monoclonal Antibody (Catalog # MAB11053-FAB2, filled histogram) or Human IgG control antibody (1-001-A, open histogram) followed by anti-Human IgG APC-conjugated secondary antibody (F0135). View our protocol for Staining Membrane-associated Proteins.

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Loading...
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IGF-I R/IGF1R

IGF-I receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta  subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I receptor is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The IGF-I receptor is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and II have been shown to be mediated via IGF-I R.

References
  1. Rechler, M.M. and S.P. Nissley (1990) in Insulin-Like Growth Factors. Sporn, M.B. and A.B. Roberts (eds): Peptide Growth Factors and Their Receptors I, New York: Springer-Verlag, p. 263.
Long Name
Insulin-like Growth Factor I Receptor
Entrez Gene IDs
3480 (Human)
Alternate Names
CD221 antigen; CD221; EC 2.7.10; EC 2.7.10.1; IGF1R; IGF-1R; IGF-I R; IGF-I receptor; IGFIR; IGF-IR; IGFR; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; JTK13; MGC142170; MGC142172; MGC18216; soluble IGF1R variant 1; soluble IGF1R variant 2

Product Datasheets

You must select a language.

x
Product Datasheet

FAQs

No product specific FAQs exist for this product, however you may

View all Antibody FAQs
Loading...

Reviews for Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody

There are currently no reviews for this product. Be the first to review Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody and earn rewards!

Have you used Human IGF-1 R/IGF1R F(ab')2 (Research Grade Teprotumumab Biosimilar) Antibody?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review