Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA

Catalog #: RDC3505 Datasheet
Catalog # Availability Size / Price Qty
RDC3505
Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA
1 Image
Product Details
FAQs
Reviews

Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

You must select a language.

x

Background: Fucosyltransferase 8/FUT8

N-glycans, O-glycans and glycolipids are frequently fucosylated at terminal sites. Therefore, fucose is often part of a sugar epitope with an important biological function. Well-known fucose-containing glycans include Lewis and ABO blood group antigens. Lewis epitopes are key elements involved in leukocyte homing and extravasation and thus are important for lymphocyte maturation and natural defense functions. Fucose-containing glycans also play critical roles in cell signaling and development. More than 10 fucosyltransferases have been cloned and all of them are Golgi-resident type II membrane proteins. FUT1 and FUT2 are alpha (1-2) fucosyltransferases and are responsible for ABO blood-group antigen synthesis. FUT3, FUT4, FUT5, FUT6, FUT7 and FUT9 are alpha (1-3) or alpha (1-4) fucosyltransferases and are responsible for Lewis antigen generation. FUT8 is the only alpha (1,6) fucosyltransferase that adds a fucose to the chitobiose core of N-glycans. The alpha 1,6-fucosylation of N-glycan in human IgG1 was reported to suppress antibody-dependent cellular cytotoxicity. Disruption of the FUT8 gene induced severe growth retardation, emphysema, and death during postnatal development in mice. The absence of alpha 1,6-fucosylation on transforming growth factor-beta 1 (TGF-beta 1) receptors was found to be involved in the mouse phenotypes. The activity of this enzyme has been measured using a phosphatase-coupled assay.

Entrez Gene IDs
2530 (Human); 53618 (Mouse); 432392 (Rat)
Alternate Names
alpha 1,6 Fucosyltransferase; alpha-(1,6)-fucosyltransferase; alpha1-6FucT; EC 2.4.1.68; fucosyltransferase 8 (alpha (1,6) fucosyltransferase); Fucosyltransferase 8; FUT8; GDP-fucose--glycoprotein fucosyltransferase; GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase; Glycoprotein 6-alpha-L-fucosyltransferase; MGC26465

FAQs

No product specific FAQs exist for this product, however you may

View all cDNA Clone FAQs

Reviews for Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA

There are currently no reviews for this product. Be the first to review Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA and earn rewards!

Have you used Human Fucosyltransferase 8 (NP_835368.1) VersaClone cDNA?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review