Home / Exostosin-like 3/EXTL3 / Human Exostosin‑like 3/EXTL3 Lumenal Domain Antibody

Human Exostosin‑like 3/EXTL3 Lumenal Domain Antibody

Catalog #: AF2635
4 Citations Datasheet
Catalog # Availability Size / Price Qty
AF2635
AF2635-SP
Product Details
Citations (4)
FAQs
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Reviews
Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Exostosin‑like 3/EXTL3 Lumenal Domain Antibody Summary

Species Reactivity
Human
Specificity
Detects human Exostosin-like 3/EXTL3 Lumenal Domain in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Exostosin-like 3/EXTL3 Lumenal Domain
Thr52-Ile919
Accession # O43909
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human Exostosin-like 3/EXTL3 Lumenal Domain

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Exostosin-like 3/EXTL3

Exostosin-like 3 (EXTL3) is an ER-resident type II transmembrane protein belonging to the EXT family of tumor suppressor genes. EXT family members are glycosyl transferases that are involved in the synthesis of the glycosaminoglycan chains of heparan sulfate proteoglycans. EXTL3 was also reported to be a receptor for the REG protein, a pancreatic beta-cell regeneration factor. The lumenal domains of human, mouse and rat share 97% amino acid sequence identity.

Entrez Gene IDs
2137 (Human)
Alternate Names
botv; DKFZp686C2342; EC 2.4.1.223; exostoses (multiple)-like 3; Exostosin like 3; Exostosin-like 3; EXTL1L; EXTL3; EXTR1BOTV; EXT-related protein 1; Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Hereditary multiple exostoses gene isolog; KIAA0519; Multiple exostosis-like protein 3; Putative tumor suppressor protein EXTL3; reg receptor; REG; REGR; RPR

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Citations for Human Exostosin‑like 3/EXTL3 Lumenal Domain Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. N-terminome analyses underscore the prevalence of SPPL3-mediated intramembrane proteolysis among Golgi-resident enzymes and its role in Golgi enzyme secretion
    Authors: Laura Hobohm, Tomas Koudelka, Fenja H. Bahr, Jule Truberg, Sebastian Kapell, Sarah-Sophie Schacht et al.
    Cellular and Molecular Life Sciences
  2. Reg-1 alpha Promotes Differentiation of Cortical Progenitors via Its N-Terminal Active Domain
    Authors: Marjorie Varilh, Isabelle Acquatella-Tran Van Ba, Michelle Silhol, Francisco Nieto-Lopez, Mireille Moussaed, Marie-Christine Lebart et al.
    Frontiers in Cell and Developmental Biology
  3. The exostosin family of glycosyltransferases: mRNA expression profiles and heparan sulfate structure in human breast carcinoma cell lines
    Authors: LF Sembajwe, K Katta, M Grønning, M Kusche-Gul
    Biosci. Rep., 2018-08-31;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. EXTL3 promoter methylation down-regulates EXTL3 and heparan sulphate expression in mucinous colorectal cancers.
    Authors: Karibe T, Fukui H, Sekikawa A, Shiratori K, Fujimori T
    J. Pathol., 2008-09-01;216(1):32-42.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

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