Human ErbB4/Her4 Antibody Summary
Glu26-Arg649
Accession # Q15303
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ErbB4/Her4
ErbB4, also called Her4 (human epidermal growth factor receptor 4), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ErbB4 ligands include the neuregulins, beta-cellulin and heparin-binding EGF-like growth factor (HB-EGF). Monomeric ErbB4 binds its ligands with low affinity. Typically, heterodimerization with ErbB2 forms the high affinity receptor complex. However, ErbB4 has also been shown to heterodimerize with both ErbB1 and ErbB3. It has been suggested that the identity of the ligand may influence the dimerization partner. Several ErbB4 isoforms exist. Two of these differ in the presence of juxtamembrane extracellular sequences which regulate the ability of TACE (TNF-alpha converting enzyme, ADAM17) to proteolytically cleave ErbB4 from the cell surface. These isoforms exhibit tissue-specific expression. Another isoform lacks the phosphoinositide 3-kinase activation sequence present in the ErbB4 cytoplasmic domain. Human ErbB4 consists of 1308 amino acids (aa) with a 25 aa signal sequence, a 626 aa extracellular domain, a 24 aa transmembrane region, and a 633 aa cytoplasmic domain. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer.
- Plowman, G.D. et al. (1993) Proc. Natl. Acad. Sci. USA 90:1746.
- Elenius, K. et al. (1997) J. Biol. Chem. 272:26761.
- Elenius, K. et al. (1999) Oncogene 18:2607.
- Rio, C. et al. (2000) J. Biol. Chem. 275:10379.
- Emkey, R. and C.R. Kahn (1997) J. Biol. Chem. 272:31172.
- Sundaresan, S. et al. (1998) Endocrinology 139:4756.
- Schaefer, G. et al. (1999) J. Biol. Chem. 274:859.
- Schlessinger, J. (2000) Cell 103:211.
- Daly, R.J. (1999) Growth Factors 16:255.
Product Datasheets
Citations for Human ErbB4/Her4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
6
Citations: Showing 1 - 6
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Acquired resistance of pancreatic cancer cells to treatment with gemcitabine and HER-inhibitors is accompanied by increased sensitivity to STAT3 inhibition
Authors: NIKOLAOS IOANNOU, ALAN M. SEDDON, ANGUS DALGLEISH, DAVID MACKINTOSH, FLAVIO SOLCA, HELMOUT MODJTAHEDI
International Journal of Oncology
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Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer
Authors: T Khan, AM Seddon, AG Dalgleish, S Khelwatty, N Ioannou, S Mudan, H Modjtahedi
Oncol Rep, 2020-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs
Authors: Helmout Modjtahedi
Int. J. Oncol., 2016-09-05;49(5):1825-1838.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: Flow Cytometry, Western Blot -
Growth response of human colorectal tumour cell lines to treatment with afatinib (BIBW2992), an irreversible erbB family blocker, and its association with expression of HER family members.
Authors: Khelwatty SA, Essapen S, Seddon AM, Modjtahedi H
Int. J. Oncol., 2011-05-25;39(2):483-91.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Anti-tumour activity of afatinib, an irreversible ErbB family blocker, in human pancreatic tumour cells
Authors: N Ioannou, A G Dalgleish, A M Seddon, D Mackintosh, U Guertler, F Solca et al.
British Journal of Cancer
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Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines
Authors: Walderik W. Zomerman, Sabine L. A. Plasschaert, Sander H. Diks, Harm-Jan Lourens, Tiny Meeuwsen-de Boer, Eelco W. Hoving et al.
PLOS ONE
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