Human Endostatin Antibody Summary
His1572-Ser1753
Accession # P39060
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Endostatin in Human Kidney. Endostatin was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human Endostatin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1098) at 5 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of immersion fixed paraffin-embedded Tissue Sections.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Endostatin
Endostatin is a 20 kDa proteolytic fragment of the C-terminal, non-collagenous (NC1) domain of type XVIII Collagen. It was originally identified as a factor produced by murine hemangioendothelioma cells that could specifically inhibit endothelial cell proliferation and angiogenesis. Although the molecular signals that trigger the release of Endostatin from type XVIII Collagen are not well understood, multiple proteases have been suggested to be involved in its generation including Cathepsins S, B, L, and V, Elastase, and matrix metalloproteinases (MMPs)-2, -7, and -9. Endostatin is of particular interest as it has been shown to inhibit the growth of many primary and metastatic tumors. It may also be involved in down-regulating angiogenesis during physiological processes such as wound healing and the establishment of placental circulation. The anti-angiogenic activity of Endostatin is attributable to its ability to inhibit endothelial cell proliferation and suppress VEGF-and FGF basic-induced endothelial cell migration and adhesion. Many of these effects are thought to be mediated by interactions between Endostatin and endothelial cell-expressed Transglutaminase 2, Heparin, and Integrins alpha 5 beta 1 and alpha V beta 3.
Product Datasheets
Citations for Human Endostatin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
7
Citations: Showing 1 - 7
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Agrin Loss in Barrett's Esophagus-Related Neoplasia and Its Utility as a Diagnostic and Predictive Biomarker
Authors: Rickelt S, Neyaz A, Condon C et al.
Clinical Cancer Research
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E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects
Authors: S Sharma, T Watanabe, T Nishimoto, T Takihara, L Mlakar, XX Nguyen, M Sanderson, Y Su, RA Chambers, C Feghali-Bo
JCI Insight, 2021-12-22;6(24):.
Species: Human
Sample Types: Cell Fractions
Applications: Western Blot -
Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue
Authors: M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund
Eur J Vasc Endovasc Surg, 2018-04-12;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Impact of p16 status on pro- and anti-angiogenesis factors in head and neck cancers.
Authors: Baruah P, Lee M, Wilson P, Odutoye T, Williamson P, Hyde N, Kaski J, Dumitriu I
Br J Cancer, 2015-07-14;113(4):653-9.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Brain malformations associated with Knobloch syndrome--review of literature, expanding clinical spectrum, and identification of novel mutations
Authors: Ahmet Okay Caglayan, Jacob F. Baranoski, Fesih Aktar, Wengi Han, Beyhan Tuysuz, Aslan Guzel et al.
Pediatric Neurology
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Expression pattern and circulating levels of endostatin in patients with pancreas cancer.
Authors: Ohlund D, Ardnor B, Oman M, Naredi P, Sund M
Int. J. Cancer, 2008-06-15;122(12):2805-10.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-Fr -
Combined antiangiogenic therapy is superior to single inhibitors in a model of renal cell carcinoma.
Authors: Bartsch G, Eggert K, Soker S, Bokemeyer C, Hautmann R, Schuch G
J. Urol., 2007-11-19;179(1):326-32.
Species: Porcine
Sample Types: Cell Lysates
Applications: Western Blot
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