Human COX-2 (NP_000954) VersaClone cDNA

Human COX-2 (NP_000954) VersaClone cDNA Summary

Specifications

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Background: COX-2

Cyclooxygenase (COX), also known as prostaglandin G/H synthase, is a membrane bound enzyme partly responsible for the catalysis of prostanoid synthesis. COX is expressed as at least three different isoforms. COX-1 is constitutively expressed and thought to regulate a number of 'housekeeping' functions such as vascular hemostasis, renal blood flow, and glomerular function. COX-2 expression is tightly regulated and induced by inflammatory mediators such as growth factors, cytokines, and endotoxin. COX-3 appears to be much more strictly regulated spatially and is observed in greatest abundance in cerebral cortex.

Related Research Areas

• Additional Reduction/Oxidation (Redox) Enzymes
• Bioactive Lipids and Receptors
• Cancer Biomarkers
• Eicosanoids and Regulators
• Macrophage Activation Markers
• Microglia Activation Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Oxidases and Oxygenases
• Oxygenases/Hydroxylases
• Redox Enzymes
• Steroid Hormones and Bioactive Lipids