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Human CD31/PECAM-1 Antibody

Catalog #: AF806
70 Citations 2 Reviews Datasheet
Catalog # Availability Size / Price Qty
AF806
AF806-SP
Detection of Human CD31/PECAM‑1 by Western Blot.
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Product Details
Citations (70)
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Reviews (2)
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Human CD31/PECAM-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human CD31 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse CD31 is observed.
Source
Polyclonal Sheep IgG
Purification
Antigen Affinity-purified
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human CD31
Extracellular domain
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Immunohistochemistry
5-25 µg/mL
Immersion fixed paraffin-embedded sections of human liver
Immunocytochemistry
5-15 µg/mL
See below
Knockout Validated
CD31/PECAM‑1 was detected in immersion fixed THP‑1 human acute monocytic leukemia cell line but is not detected in CD31/PECAM‑1 knockout (KO) THP‑1 human cell line.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human CD31/PECAM-1 antibody by Western Blot. View Larger

Detection of Human CD31/PECAM‑1 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (HAF016). A specific band was detected for CD31/PECAM-1 at approximately 130 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Immunocytochemistry CD31/PECAM-1 antibody in HUVECs by Immunocytochemistry (ICC). View Larger

CD31/PECAM‑1 in HUVECs. CD31/PECAM-1 was detected in immersion fixed HUVEC human umbilical vein endothelial cells using 10 µg/mL Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.

Simple Western Detection of Human CD31/PECAM-1 antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Human CD31/PECAM‑1 by Simple WesternTM. Simple Western lane view shows lysates of Jurkat human acute T cell leukemia cell line and HepG2 human hepatocellular carcinoma cell line, loaded at 0.2 mg/mL. A specific band was detected for CD31/PECAM-1 at approximately 173-186 kDa (as indicated) using 10 µg/mL of Sheep Anti-Human CD31/PECAM-1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) followed by 1:50 dilution of HRP-conjugated Anti-Sheep IgG Secondary Antibody (HAF016). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Knockout Validated View Larger

CD31/PECAM‑1 Specificity is Shown by Immunocytochemistry in Knockout Cell Line. CD31/PECAM‑1 was detected in immersion fixed THP‑1 human acute monocytic leukemia cell line but is not detected in CD31/PECAM‑1 knockout (KO) THP‑1 human cell line using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; NL010) and counterstained with DAPI (blue). Specific staining was localized to cell membrane. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Immunohistochemistry View Larger

Detection of CD31/PECAM‑1 in human liver. CD31/PECAM‑1 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry View Larger

Detection of CD31/PECAM‑1 in human liver. CD31/PECAM‑1 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human CD31/PECAM‑1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF806) at 5 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (Catalog # VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using VisUCyte Antigen Retrieval Reagent-Basic (Catalog # VCTS021). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to endothelial cells and sinusoids. View our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunocytochemistry/ Immunofluorescence Detection of Human CD31/PECAM-1 by Immunocytochemistry/Immunofluorescence View Larger

Detection of Human CD31/PECAM-1 by Immunocytochemistry/Immunofluorescence Expression pattern of integrin receptors and type IV collagen in normal pancreatic tissue. A. H&E staining of normal exocrine pancreas with acini structures and a duct in the insert. The area shown is representative for all panels in B. B. Merged immunofluorescence staining of integrin alpha 1, alpha 2, and beta 1 (in red), and type IV collagen (green in upper row), or the endothelial marker CD31 (green in lower row). Type IV collagen is present in the vascular-, ductal-, and acini-BMs. Integrin alpha 1 is only expressed in endothelial cells and integrin alpha 2 only in the ductal epithelium. Integrin beta 1 is found in the ductal-, endothelial-, and at the base of the acini-cells. Arrows indicate examples of colocalization. Magnification x40 in all panels. Cell nuclei are stained by DAPI (in blue). Image collected and cropped by CiteAb from the following publication (https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-154), licensed under a CC-BY license. Not internally tested by R&D Systems.

Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CD31/PECAM-1

The CD31 adhesion molecule, also known as PECAM-1, is expressed in large amounts on endothelial cells at intercellular junctions and on T cell subsets, and to a lesser extent on platelets and most other leukocytes such as monocytes and neutrophils. CD31 binds to itself homotypically, and also to the leukocyte integrin alpha v beta 3 heterotypically. CD31 is required for the transendothelial migration of leukocytes through intercellular junctions of vascular endothelial cells. CD31 has been found in human plasma, and the presence of this circulating isoform is suggested to modulate the transendothelial migration of leukocytes.

Long Name
Platelet Endothelial Cell Adhesion Molecule 1
Entrez Gene IDs
5175 (Human); 18613 (Mouse); 29583 (Rat)
Alternate Names
adhesion molecule; CD31 antigen; CD31; CD31/EndoCAM; EndoCAM; FLJ34100; FLJ58394; GPIIA'; PECA1; PECAM1; PECAM-1; PECAM-1, CD31/EndoCAM; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1; platelet/endothelial cell adhesion molecule

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Citations for Human CD31/PECAM-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

70 Citations: Showing 1 - 10
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  1. A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
    Authors: Lyu Z, Park J, Kim KM Et al.
    Nature biomedical engineering
  2. SARS-CoV-2 infection induces beta cell transdifferentiation
    Authors: Tang X, Uhl S, Zhang T et al.
    Cell Metabolism
  3. SOX4 promotes vascular abnormality in glioblastoma and is a novel target to improve drug delivery
    Authors: Yao, K;Yang, M;Shu, M;Wang, T;Gao, D;Zhou, L;Wang, G;Zhang, Z;Tang, J;
    Translational oncology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  4. Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic ? cell Pyroptosis upon Viral Infection
    Authors: Yang, L;Han, Y;Zhang, T;Dong, X;Ge, J;Roy, A;Zhu, J;Lu, T;Vandana, JJ;de Silva, N;Robertson, CC;Xiang, JZ;Pan, C;Sun, Y;Que, J;Evans, T;Liu, C;Wang, W;Naji, A;Parker, SCJ;Schwartz, RE;Chen, S;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  5. Engineered human iPS cell models reveal altered podocytogenesis and glomerular capillary wall in CHD-associated SMAD2 mutations
    Authors: Bhattacharya, R;Ward, T;Kalejaiye, TD;Mishra, A;Leeman, S;Arzaghi, H;Seidman, JG;Seidman, CE;Musah, S;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  6. Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence
    Authors: Li, B;Xiong, W;Zuo, W;Shi, Y;Wang, T;Chang, L;Wu, Y;Ma, H;Bian, Q;Chang, ACY;
    Nucleic acids research
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  7. Dietary emulsifier polysorbate 80 exposure accelerates age-related cognitive decline
    Authors: Zhang, L;Yin, Z;Liu, X;Jin, G;Wang, Y;He, L;Li, M;Pang, X;Yan, B;Jia, Z;Ma, J;Wei, J;Cheng, F;Li, D;Wang, L;Han, Z;Liu, Q;Chen, F;Cao, H;Lei, P;
    Brain, behavior, and immunity
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  8. Multisensory gamma stimulation promotes glymphatic clearance of amyloid
    Authors: Murdock, MH;Yang, CY;Sun, N;Pao, PC;Blanco-Duque, C;Kahn, MC;Kim, T;Lavoie, NS;Victor, MB;Islam, MR;Galiana, F;Leary, N;Wang, S;Bubnys, A;Ma, E;Akay, LA;Sneve, M;Qian, Y;Lai, C;McCarthy, MM;Kopell, N;Kellis, M;Piatkevich, KD;Boyden, ES;Tsai, LH;
    Nature
    Species: Human
    Sample Types: Organoid
    Applications: Immunohistochemistry
  9. Generation of complex bone marrow organoids from human induced pluripotent stem cells
    Authors: Frenz-Wiessner, S;Fairley, SD;Buser, M;Goek, I;Salewskij, K;Jonsson, G;Illig, D;Zu Putlitz, B;Petersheim, D;Li, Y;Chen, PH;Kalauz, M;Conca, R;Sterr, M;Geuder, J;Mizoguchi, Y;Megens, RTA;Linder, MI;Kotlarz, D;Rudelius, M;Penninger, JM;Marr, C;Klein, C;
    Nature methods
    Species: Human, Xenograft
    Sample Types: Organoid, Whole Tissue
    Applications: Immunohistochemistry
  10. Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias
    Authors: Raval, AN;Schmuck, EG;Roy, S;Saito, Y;Zhou, T;Conklin, J;Hacker, TA;Koonce, C;Boyer, M;Stack, K;Hebron, E;Nagle, SK;Hsieh, PCH;Kamp, TJ;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Immunocytochemistry
  11. Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1?/ASK1/JNK signaling pathway in mice with traumatic brain injury
    Authors: Shi, G;Liu, L;Cao, Y;Ma, G;Zhu, Y;Xu, J;Zhang, X;Li, T;Mi, L;Jia, H;Zhang, Y;Liu, X;Zhou, Y;Li, S;Yang, G;Liu, X;Chen, F;Wang, B;Deng, Q;Zhang, S;Zhang, J;
    Journal of neuroinflammation
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  12. Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding
    Authors: Elizabeth S. Taglauer, Elisha M. Wachman, Lillian Juttukonda, Timothy Klouda, Jiwon Kim, Qiong Wang et al.
    The American Journal of Pathology
  13. Multi-omics profiling visualizes dynamics of cardiac development and functions
    Authors: Y Gu, Y Zhou, S Ju, X Liu, Z Zhang, J Guo, J Gao, J Zang, H Sun, Q Chen, J Wang, J Xu, Y Xu, Y Chen, Y Guo, J Dai, H Ma, C Wang, G Jin, C Li, Y Xia, H Shen, Y Yang, X Guo, Z Hu
    Cell Reports, 2022-12-27;41(13):111891.
    Species: Mouse
    Sample Types: Whole Cells
  14. Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy-induced toxicities
    Authors: JKE Spetz, MHC Florido, CS Fraser, X Qin, J Choiniere, SJ Yu, R Singh, M Friesen, LL Rubin, JE Salem, JJ Moslehi, KA Sarosiek
    Science Advances, 2022-11-09;8(45):eabn6579.
    Species: Human, Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  15. Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling
    Authors: Shin HS, Thakore A, Tada Y et al.
    Scientific Reports
  16. Blocking C3d+/GFAP+ A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke
    Authors: Qi Zhang, Chang Liu, Rubing Shi, Shiyi Zhou, Huimin Shan, Lidong Deng et al.
    Aging and disease
  17. Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy
    Authors: Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro et al.
    iScience
  18. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
    Authors: Timothy Klouda, Yuan Hao, Hyunbum Kim, Jiwon Kim, Judith Olejnik, Adam J. Hume et al.
    Angiogenesis
  19. Senescence-induced endothelial phenotypes underpin immune-mediated senescence surveillance
    Authors: Kelvin Yin, Daniel Patten, Sarah Gough, Susana de Barros Gonçalves, Adelyne Chan, Ioana Olan et al.
    Genes & Development
  20. Platinum Chemotherapy Induces Lymphangiogenesis in Cancerous and Healthy Tissues That Can be Prevented With Adjuvant Anti-VEGFR3 Therapy
    Authors: Alexandra R. Harris, Savieay Esparza, Mohammad S. Azimi, Robert Cornelison, Francesca N. Azar, Danielle C. Llaneza et al.
    Frontiers in Oncology
  21. Short-Term Supplementation With Fermented Red Clover Extract Reduces Vascular Inflammation in Early Post-menopausal Women
    Authors: Kate A. Wickham, Line B. Nørregaard, Mikkel Oxfeldt, Stephen S. Cheung, Lasse Gliemann, Mette Hansen et al.
    Frontiers in Cardiovascular Medicine
  22. Pharmacokinetic Developability and Disposition Profiles of Bispecific Antibodies: A Case Study with Two Molecules
    Authors: Amita Datta-Mannan, Robin Brown, Stephanie Key, Paul Cain, Yiqing Feng
    Antibodies (Basel)
  23. Hydrogels Containing Gradients in Vascular Density Reveal Dose‐Dependent Role of Angiocrine Cues on Stem Cell Behavior
    Authors: Mai T. Ngo, Victoria R. Barnhouse, Aidan E. Gilchrist, Bhushan P. Mahadik, Christine J. Hunter, Joy N. Hensold et al.
    Advanced Functional Materials
  24. A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium
    Authors: Y Roye, R Bhattachar, X Mou, Y Zhou, MA Burt, S Musah
    Micromachines, 2021-08-16;12(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  25. Key molecular alterations in endothelial cells in human glioblastoma uncovered through single-cell RNA sequencing
    Authors: Y Xie, L He, R Lugano, Y Zhang, H Cao, Q He, M Chao, B Liu, Q Cao, J Wang, Y Jiao, Y Hu, L Han, Y Zhang, H Huang, L Uhrbom, C Betsholtz, L Wang, A Dimberg, L Zhang
    JCI Insight, 2021-08-09;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  26. SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta
    Authors: LB Argueta, LA Lacko, Y Bram, T Tada, L Carrau, T Zhang, S Uhl, BC Lubor, V Chandar, C Gil, W Zhang, B Dodson, J Bastiaans, M Prabhu, CM Salvatore, YJ Yang, RN Baergen, BR tenOever, NR Landau, S Chen, RE Schwartz, H Stuhlmann
    bioRxiv : the preprint server for biology, 2021-06-17;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  27. Mechanisms of angiogenic incompetence in Hutchinson-Gilford progeria via downregulation of endothelial NOS
    Authors: YG Gete, LW Koblan, X Mao, M Trappio, B Mahadik, JP Fisher, DR Liu, K Cao
    Aging Cell, 2021-06-04;0(0):e13388.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: IHC, Western Blot
  28. In Vitro Prevascularization of Self-Assembled Human Bone-Like Tissues and Preclinical Assessment Using a Rat Calvarial Bone Defect Model
    Authors: Fabien Kawecki, Todd Galbraith, William P. Clafshenkel, Michel Fortin, François A. Auger, Julie Fradette
    Materials (Basel)
  29. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration
    Authors: KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh
    Cell Stem Cell, 2021-03-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  30. Generation, functional analysis and applications of isogenic three-dimensional self-aggregating cardiac microtissues from human pluripotent stem cells
    Authors: G Campostrin, V Meraviglia, E Giacomelli, RWJ van Helden, L Yiangou, RP Davis, M Bellin, VV Orlova, CL Mummery
    Nature Protocols, 2021-03-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  31. Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development
    Authors: EI Crosse, S Gordon-Key, S Rybtsov, A Binagui-Ca, H Felchle, NC Nnadi, K Kirschner, T Chandra, S Tamagno, DJ Webb, F Rossi, RA Anderson, A Medvinsky
    Cell Stem Cell, 2020-09-17;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  32. Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu
    Authors: Dongdong Zhang, Andrew J. Kinloch, Abhinav Srinath, Robert Shenkar, Romuald Girard, Rhonda Lightle et al.
    Journal of Autoimmunity
  33. Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia
    Authors: CJ Mietus, TJ Lackner, PS Karvelis, GT Willcockso, CM Shields, NG Lambert, P Koutakis, MA Fuglestad, H Hernandez, GR Haynatzki, JKS Kim, HK DeSpiegela, II Pipinos, GP Casale
    J Clin Med, 2020-08-08;9(8):.
    Species: Bovine, Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  34. Metabolic response of blood vessels to TNF alpha
    Authors: Abidemi Junaid, Johannes Schoeman, Wei Yang, Wendy Stam, Alireza Mashaghi, Anton Jan van Zonneveld et al.
    eLife
  35. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Organoids, Whole Cells
    Applications: ICC, IHC
  36. Conditioned medium produced by fibroblasts cultured in low oxygen pressure allows the formation of highly structured capillary-like networks in fibrin gels
    Authors: C Caneparo, C Baratange, S Chabaud, S Bolduc
    Sci Rep, 2020-06-09;10(1):9291.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  37. Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
    Authors: JW Blanchard, M Bula, J Davila-Vel, LA Akay, L Zhu, A Frank, MB Victor, JM Bonner, H Mathys, YT Lin, T Ko, DA Bennett, HP Cam, M Kellis, LH Tsai
    Nat. Med., 2020-06-08;26(6):952-963.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  38. Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease
    Authors: E Giacomelli, V Meraviglia, G Campostrin, A Cochrane, X Cao, RWJ van Helden, A Krotenberg, M Mircea, S Kostidis, RP Davis, BJ van Meer, CR Jost, AJ Koster, H Mei, DG Míguez, AA Mulder, M Ledesma-Te, G Pompilio, L Sala, DCF Salvatori, RC Slieker, E Sommariva, AAF de Vries, M Giera, S Semrau, LGJ Tertoolen, VV Orlova, M Bellin, CL Mummery
    Cell Stem Cell, 2020-05-26;26(6):862-879.e11.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  39. Daily Ethanol Drinking Followed by an Abstinence Period Impairs Bone Marrow Niche and Mitochondrial Function of Hematopoietic Stem/Progenitor Cells in Rhesus Macaques
    Authors: Oleg Varlamov, Matthew Bucher, Leslie Myatt, Natali Newman, Kathleen A. Grant
    Alcoholism: Clinical and Experimental Research
  40. Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques
    Authors: Jacob J. Robino, Nathalie Pamir, Sara Rosario, Lindsey B. Crawford, Benjamin J. Burwitz, Charles T. Roberts et al.
    Bone
  41. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  42. Platelets, endothelial cells and leukocytes contribute to the exercise-triggered release of extracellular vesicles into the circulation
    Authors: Alexandra Brahmer, Elmo Neuberger, Leona Esch-Heisser, Nils Haller, Malene Moeller Jorgensen, Rikke Baek et al.
    Journal of Extracellular Vesicles
  43. Mineral deposition and vascular invasion of hydroxyapatite reinforced collagen scaffolds seeded with human adipose-derived stem cells
    Authors: HE Weiss-Bilk, MJ Meagher, JA Gargac, GL Niebur, RK Roeder, DR Wagner
    Biomater Res, 2019-10-17;23(0):15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flourescense Microscopy
  44. Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition
    Authors: JM Elsakr, JC Dunn, K Tennant, SK Zhao, K Kroeten, RC Pasek, DL Takahashi, TA Dean, DR Velez Edwa, CE McCurdy, KM Aagaard, AC Powers, JE Friedman, P Kievit, M Gannon
    Mol Metab, 2019-04-12;0(0):.
    Species: Primate - Macaca fuscata (Japanese Macaque)
    Sample Types: Whole Tissue
    Applications: IHC-P
  45. Expression and localisation of thymosin beta-4 in the developing human early fetal heart
    Authors: Vinay Saunders, Jennifer M. Dewing, Tilman Sanchez-Elsner, David I. Wilson
    PLOS ONE
  46. Tissue-engineered 3D melanoma model with blood and lymphatic capillaries for drug development
    Authors: J Bourland, J Fradette, FA Auger
    Sci Rep, 2018-09-04;8(1):13191.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  47. Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration
    Authors: Angela Rey-Gallardo, Hannah Tomlins, Justin Joachim, Izajur Rahman, Phoebe Kitscha, Karen Frudd et al.
    Journal of Cell Science
  48. Circulating Vascular Basement Membrane Fragments are Associated with the Diameter of the Abdominal Aorta and Their Expression Pattern is Altered in AAA Tissue
    Authors: M Holsti, A Wanhainen, C Lundin, M Björck, G Tegler, J Svensson, M Sund
    Eur J Vasc Endovasc Surg, 2018-04-12;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  49. Leucine-Rich ?-2-Glycoprotein-1 (LRG-1) Expression in Retinoblastoma
    Authors: R Amer, L Tiosano, J Pe'er
    Invest. Ophthalmol. Vis. Sci., 2018-02-01;59(2):685-692.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  50. Tissue-engineered 3D human lymphatic microvascular network for in vitro studies of lymphangiogenesis
    Authors: L Gibot, T Galbraith, J Bourland, A Rogic, M Skobe, FA Auger
    Nat Protoc, 2017-04-27;12(5):1077-1088.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  51. Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells
    Sci Rep, 2016-11-02;6(0):35680.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  52. Adjuvant capecitabine plus bevacizumab versus capecitabine alone in patients with colorectal cancer (QUASAR 2): an open-label, randomised phase 3 trial
    Authors: Rachel S Kerr, Sharon Love, Eva Segelov, Elaine Johnstone, Beverly Falcon, Peter Hewett et al.
    The Lancet Oncology
  53. Aberrant bispecific antibody pharmacokinetics linked to liver sinusoidal endothelium clearance mechanism in cynomolgus monkeys
    Authors: A Datta-Mann, JE Croy, L Schirtzing, S Torgerson, M Breyer, VJ Wroblewski
    MAbs, 2016-07-01;8(5):969-82.
    Species: Primate
    Sample Types: Whole Cells
    Applications: ICC
  54. Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression
    Authors: Madeleine J. Oudin, Shannon K. Hughes, Nazanin Rohani, Mira N. Moufarrej, Joan G. Jones, John S. Condeelis et al.
    Clinical & Experimental Metastasis
  55. Cell-based approach for 3D reconstruction of lymphatic capillaries in vitro reveals distinct functions of HGF and VEGF-C in lymphangiogenesis
    Authors: Laure Gibot, Todd Galbraith, Bryan Kloos, Suvendu Das, Dan A. Lacroix, François A. Auger et al.
    Biomaterials
  56. Oxidative activity of 17 beta -hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17 beta -HSD type 2
    Authors: Mohamed Fouad Mansour, Mélissa Pelletier, Marie-Michèle Boulet, Dominique Mayrand, Gaétan Brochu, Stefane Lebel et al.
    Molecular and Cellular Endocrinology
  57. TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis.
    Authors: Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J
    Oncogene, 2015-05-11;35(6):748-60.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  58. A BMP7 Variant Inhibits Tumor Angiogenesis In Vitro and In Vivo through Direct Modulation of Endothelial Cell Biology.
    Authors: Tate C, Mc Entire J, Pallini R, Vakana E, Wyss L, Blosser W, Ricci-Vitiani L, D'Alessandris Q, Morgante L, Giannetti S, Larocca L, Todaro M, Benfante A, Colorito M, Stassi G, De Maria R, Rowlinson S, Stancato L
    PLoS ONE, 2015-04-28;10(4):e0125697.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC-Fr
  59. Creating capillary networks within human engineered tissues: Impact of adipocytes and their secretory products
    Authors: Kim Aubin, Caroline Vincent, Maryse Proulx, Dominique Mayrand, Julie Fradette
    Acta Biomaterialia
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  60. IGFBP-4 and -5 are expressed in first-trimester villi and differentially regulate the migration of HTR-8/SVneo cells.
    Authors: Crosley, Erin J, Dunk, Caroline, Beristain, Alexande, Christians, Julian K
    Reprod Biol Endocrinol, 2014-12-04;12(0):123.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  61. Consumption of a Western-style diet during pregnancy impairs offspring islet vascularization in a Japanese macaque model.
    Authors: Pound L, Comstock S, Grove K
    Am J Physiol Endocrinol Metab, 2014-05-20;307(1):E115-23.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Tissue
    Applications: IHC-P
  62. A method to assess target gene involvement in angiogenesis in vitro and in vivo using lentiviral vectors expressing shRNA.
    Authors: Blosser, Wayne, Vakana, Eliza, Wyss, Lisa V, Swearingen, Michelle, Stewart, Julie, Stancato, Louis, Tate, Courtney
    PLoS ONE, 2014-04-23;9(4):e96036.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  63. miR-27a regulates endothelial differentiation of breast cancer stem like cells.
    Authors: Tang, W, Yu, F, Yao, H, Cui, X, Jiao, Y, Lin, L, Chen, J, Yin, D, Song, E, Liu, Q
    Oncogene, 2013-06-10;33(20):2629-38.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr, Western Blot
  64. Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop.
    Authors: Ohlund D, Franklin O, Lundberg E, Lundin C, Sund M
    BMC Cancer, 2013-03-26;13(0):154.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC-Fr
  65. Maternal high-fat diet impacts endothelial function in nonhuman primate offspring.
    Authors: Fan, L, Lindsley, S R, Comstock, S M, Takahashi, D L, Evans, A E, He, G-W, Thornburg, K L, Grove, K L
    Int J Obes (Lond), 2012-03-27;37(2):254-62.
    Species: Primate - Macaca fuscata (Japanese Macaque)
    Sample Types: Whole Tissue
    Applications: IHC-P
  66. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures.
    Authors: Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S, Mayr M
    Blood, 2009-04-15;114(3):723-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  67. Signaling hierarchy regulating human endothelial cell development.
    Authors: Kelly MA, Hirschi KK
    Arterioscler. Thromb. Vasc. Biol., 2009-02-12;29(5):718-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  68. Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.
    Authors: Shen HC, He M, Powell A, Adem A, Lorang D, Heller C, Grover AC, Ylaya K, Hewitt SM, Marx SJ, Spiegel AM, Libutti SK
    Cancer Res., 2009-02-10;69(5):1858-66.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  69. The Endothelial Mechanotransduction Protein Platelet Endothelial Cell Adhesion Molecule-1 Is Influenced by Aging and Exercise Training in Human Skeletal Muscle.
    Authors: Gliemann L, Rytter N, Piil P et al.
    Front Physiol
  70. Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody
    Authors: G Jo, J Bae, HJ Hong, AR Han, DK Kim, SP Hong, JA Kim, S Lee, GY Koh, HM Kim
    Nature Communications, 2021-11-01;12(1):6287.

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Human CD31/PECAM-1 Antibody
By Anonymous on 05/27/2022
Application: WB Sample Tested: Cell Lysates Species: Human
Western Blot Human CD31/PECAM-1 Antibody AF806
Human CD31/PECAM-1 Antibody
By Karina Kinghorn on 08/04/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: HUVEC human umbilical vein endothelial cells Species: Human
Immunocytochemistry/Immunofluorescence Human CD31/PECAM-1 Antibody AF806