Human CD3 epsilon (NP_000724) VersaClone cDNA

Human CD3 epsilon (NP_000724) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CD3 epsilon

The T cell receptor (TCR)/CD3 complex consists of two variable antigen-recognition receptor chains (TCR-alpha/TCR-beta or TCR-gamma/TCR-delta) that are non-covalently linked to at least four different invariant chains: CD3 gamma, CD3 delta, CD3 epsilon, and the CD3 zeta chain that exists as either a homodimer or as a heterodimer with its splice-variant the CD3 eta chain. The CD3 complex functions to transduce intracellular signals during TCR antigen recognition. CD3 is expressed early in thymocyte development, and on a subset of NK cells. CD3 epsilon is one of at least three invariant proteins that associate with the variable antigen recognition chains of the T cell receptor and function in signal transduction.

Related Research Areas

• ITIM/ITAM Immunoreceptors and Related Molecules
• Leukocyte Receptors/Markers in Allergy and Asthma
• Regulatory T Cells (Tregs)
• T Cell Antigen Recognition
• Th1 Cells
• Th17 Cells
• Th2 Cells
• Th22 Cells
• Th9 Cells