Human CD14 (NP_000582) VersaClone cDNA

Human CD14 (NP_000582) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CD14

CD14 is an acute phase glycoprotein that binds lipopolysaccharide endotoxins (LPS) from Gram-negative bacteria. It is primarily expressed on monocytes, macrophages, and neutrophils, and soluble forms can be secreted or shed from the cell surface. CD14 accepts LPS from its initial binding by LBP, and it can further transfer LPS to the TLR4/MD2 complex. LPS acctivation of TLR4 triggers inflammatory activation. CD14 also contributes to the response to TLR3 ligands, phosphoinositides, as well as the surfactant proteins SP-A and SP-D.

Related Research Areas

• Common Macrophage Markers
• Conventional/Classical Dendritic Cells
• Immune Regulatory Molecules on Endothelial Cells
• Inflammatory Mediators
• Inflammatory/Monocyte-derived Dendritic Cells
• Langerhans and Dermal Dendritic Cells
• Leukocyte Receptors/Markers in Allergy and Asthma
• MDSC Phenotyping - Negative Markers
• Microglia Activation
• Monocyte Markers
• Myeloid Lineage Markers
• Plasmacytoid Dendritic Cells
• Toll-Like Receptors
• Uptake of Amyloid beta by Glia Cells
• Uptake of Amyloid beta by Macrophages