Human CCL17/TARC PE-conjugated Antibody Summary
Ala24-Ser94
Accession # Q92583.1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCL17/TARC in A549 Human Cell Line by Flow Cytometry. A549 human lung carcinoma cell line was stained with Mouse Anti-Human CCL17/TARC PE-conjugated Monoclonal Antibody (Catalog # IC3641P, filled histogram) or isotype control antibody (IC002P, open histogram). To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer (FC004) and permeabilized with Flow Cytometry Permeabilization/Wash Buffer I (FC005). Staining was performed using our Staining Intracellular Molecules protocol.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCL17/TARC
CCL17, also called TARC, is a member of the CC chemokine family. CCL17 cDNA encodes a highly basic 94 amino acid (aa) residue precursor protein with a 23 aa residue signal peptide that is cleaved to generate the 71 aa residue mature secreted protein. Among CC chemokine family members, CCL17 has approximately 24‑29% amino acid sequence identity with CCL1, 2, 3, 4, 5, 7 and 8. The gene for human CCL17 has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. CCL17 is constitutively expressed in thymus, and at a lower level in lung, colon, and small intestine. CCL17 is also transiently expressed in stimulated peripheral blood mononuclear cells. Recombinant CCL17 has been shown to be chemotactic for T cell lines but not monocytes or neutrophils. CCL17 was identified to be a specific functional ligand for CCR4, a receptor that is selectively expressed on T cells.
- Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
- Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
- Nomiyama, H. et al. (1997) Genomics 40:211.
Product Datasheets
Citations for Human CCL17/TARC PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Human Decidual CD1a+ Dendritic Cells Undergo Functional Maturation Program Mediated by Gp96
Authors: T Gulic, G Laskarin, L Glavan, T Grubi? Kez, H Haller, D Rukavina
International Journal of Molecular Sciences, 2023-01-23;24(3):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer.
Authors: Mizukami Y, Kono K, Kawaguchi Y, Akaike H, Kamimura K, Sugai H, Fujii H
Int. J. Cancer, 2008-05-15;122(10):2286-93.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.
Authors: Christophi GP, Hudson CA, Gruber RC, Christophi CP, Mihai C, Mejico LJ, Jubelt B, Massa PT
Lab. Invest., 2008-01-21;88(3):243-55.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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