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Human Cathepsin V Antibody

Catalog #: MAB10801
1 Citation Datasheet
Catalog # Availability Size / Price Qty
MAB10801
MAB10801-SP
Product Details
Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Cathepsin V Antibody Summary

Species Reactivity
Human
Specificity
Detects human Cathepsin V in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with recombinant human (rh) Cathepsin B, C, F, K, L, O, S, or Z is observed. In Western blots, less than 5% cross‑reactivity with rhCathepsin K and no corss-reactivity with rhCathepsin B, C, F, L, O, S, or Z is observed. This antibody specifically identifies the pro form but not the active form of Cathepsin V in Western blots.
Source
Monoclonal Mouse IgG2B Clone # 182021
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Cathepsin V
Val18-Val334
Accession # O60911
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Cathepsin V (Catalog # 1080-CY)
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human Cathepsin V (Catalog # 1080-CY), see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Cathepsin V

Cathepsin V, also known as cathepsin L2 and cathepsin U, is a lysosomal cysteine protease expressed in the thymus, testis, and corneal epithelium. It may play a role in tumor progression since it is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues. Additionally, it may be involved in corneal physiology. The amino acid sequence of human Cathepsin V shares 99%, 83% and 76% identical with that of chimpanzee, dog and mouse/rat, respectively.

Entrez Gene IDs
1515 (Human)
Alternate Names
Cathepsin L2; Cathepsin U; Cathepsin V; CATL2; CTSL2; CTSUcathepsin L2, preproprotein; CTSVMGC125957; EC 3.4.22; EC 3.4.22.43

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Citation for Human Cathepsin V Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence
    Authors: Chan Li, Zhaoya Liu, Mengshi Chen, Liyang Zhang, Ruizheng Shi, Hua Zhong
    Biology (Basel)

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