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Human Bcl-2 aa 41-54 Antibody

Catalog #: 2291-MC
2 Citations Datasheet

Discontinued Product

2291-MC has been discontinued.
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Citations (2)
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Human Bcl-2 aa 41-54 Antibody Summary

Species Reactivity
Human
Specificity
Anti-Bcl-2 (Clone YTH-8C8) reacts with human Bcl-2.
Source
Monoclonal Mouse IgG1 Clone # YTH-8C8
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human Bcl-2
aa 41-54
Formulation
This antibody is provided as purified immunoglobulin from mouse ascites in 1X PBS containing 0.01% sodium azide and 50% glycerol.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1:1000 dilution
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at -20 °C.

Background: Bcl-2

The Bcl-2 family of proteins plays a crucial role in the regulation of cell death in many eukaryotic systems. The Bcl-2 gene was initially isolated from the t(14;18) chromosomal translocation found in human B-cell follicular lymphomas and was subsequently shown to repress cell death triggered by a diverse array of stimuli. However, the biochemical process by which Bcl-2 regulates cell death is poorly understood.

References
  1. Suzuki, M. et al. 2000, Cell 103:645-54.
  2. Hsu, Y.-T. et al. 1997, Proc. Natl. Acad. Sci. USA 94:3668-3672.
  3. Hsu, Y.-T. and R.J. Youle. 1997, J. Biol. Chem. 272:13829-13834.
  4. Neuchushtan, A. et al. 1999, EMBO J. 18:2330-2341.
Long Name
B Cell Lymphoma/Leukemia 2
Entrez Gene IDs
596 (Human); 12043 (Mouse); 24224 (Rat)
Alternate Names
apoptosis regulator Bcl-2; B-cell CLL/lymphoma 2; Bcl2; Bcl-2

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Citations for Human Bcl-2 aa 41-54 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis
    Oncogene, 2016-11-21;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Photochemically mediated delivery of AdhCMV-TRAIL augments the TRAIL-induced apoptosis in colorectal cancer cell lines.
    Authors: Engesaeter BØ, Bonsted A, Lillehammer T, Engebraaten O, Berg K, Maelandsmo GM
    Cancer Biol. Ther., 2006-11-19;5(11):1511-20.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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