Human alpha -Synuclein Alexa Fluor® 405-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: alpha-Synuclein

alpha -Synuclein is member of a family of small soluble proteins that include also beta -, and gamma -Synuclein. It is predominantly expressed in neurons of the central nervous system in the presynaptic region of nerve terminals, where it cycles between a free, partially unfolded and a helical, membrane-bound form. alpha -Synuclein can self-aggregate in vivo and in vitro, forming various oligomeric species and fibrillar and amorphous aggregates. The fibrils and amyloidal forms of alpha -Synuclein are major components of Lewy bodies and Lewy neurites and have been linked to the pathogenesis of Parkinson’s Disease, Parkinson’s Disease Dementia, and dementia with Lewy bodies. alpha -Synuclein aggregates can be also found associated with amyloid plaques in Alzheirmer’s Disease.

Product Datasheets

Related Research Areas

• ALS Related Molecules
• Microglia Activation
• Neurofibrillary Tangle Formation
• Neuronal Lineage Markers
• Parkinson's Disease Related Molecules
• Synaptic Proteins
• Synaptic SNAREs