Human 5-HT2B APC-conjugated Antibody Summary
Accession # P41595
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of 5-HT2B in HEK293 cell transfected with 5-HT2B and eGFP vs irrelevant cells by Flow Cytometry. HEK293 cell transfected with 5-HT2B and eGFP vs irrelevant was stained with eGFP and Rabbit Anti-Human 5-HT2B APC‑conjugated Monoclonal Antibody (Catalog # FAB11297A) in 5-HT2B transfectants (A) or (B) irrelevant transfectants. View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: 5-HT2B
HTR2B is a G-protein coupled receptor for serotonin. The 5HT2 receptors mediate many of the central and peripheral physiologic functions of serotonin. 5HT2B plays a role in the regulation of dopamine and serotonin release, serotonin uptake and in the regulation of extracellular dopamine and serotonin levels. It also plays a role in pulmonary vasoconstriction and regulating cardiac structure and functions. 5HT2B receptors were shown to be expressed in human failing heart and have been strongly implicated in drug induced valvular heart disease.
Product Datasheets
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