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Human 5-HT2B Antibody

Catalog #: MAB10322
1 Citation Datasheet
Catalog # Availability Size / Price Qty
MAB10322-100
MAB10322-SP
5-HT2B in Mouse Cerebellum.
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Citations (1)
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Human 5-HT2B Antibody Summary

Species Reactivity
Human
Specificity
Detects human 5-HTR2B in direct ELISAs.
Source
Monoclonal Mouse IgG2A Clone # 1014838
Purification
Protein A or G purified from ascites
Immunogen
Synthetic peptide containing human 5- HTR2B
Accession # P41595
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunohistochemistry
8-25 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry 5-HT2B antibody in Mouse Cerebellum by Immunohistochemistry (IHC-P). View Larger

5-HT2B in Mouse Cerebellum. 5-HT2B was detected in immersion fixed paraffin-embedded sections of mouse cerebellum using Mouse Anti-Human 5-HT2B Monoclonal Antibody (Catalog # MAB10322) at 8 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to Purkinje neurons.

Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: 5-HT2B

HTR2B is a G-protein coupled receptor for serotonin. The 5HT2 receptors mediate many of the central and peripheral physiologic functions of serotonin. 5HT2B plays a role in the regulation of dopamine and serotonin release, serotonin uptake and in the regulation of extracellular dopamine and serotonin levels. It also plays a role in pulmonary vasoconstriction and regulating cardiac structure and functions. 5HT2B receptors were shown to be expressed in human failing heart and have been strongly implicated in drug induced valvular heart disease.

Long Name
5-Hydroxytryptamine Receptor 2B
Entrez Gene IDs
3357 (Human); 15559 (Mouse); 29581 (Rat)
Alternate Names
5-HT(2B); 5HT2B; 5-HT2B; 5-HT-2B; 5-HT2B5-HT 2B receptor; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; HTR2B; Serotonin receptor 2B

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Citation for Human 5-HT2B Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome
    Authors: Li, ZY;Mao, YQ;Hua, Q;Sun, YH;Wang, HY;Ye, XG;Hu, JX;Wang, YJ;Jiang, M;
    World journal of gastroenterology
    Species: Human, Rat
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry

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