Human 15-PGDH/HPGD Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: 15-PGDH/HPGD

HPGD, or 15-hydroxyprostaglandin dehydrogenase, is a NAD⁺-linked dehydrogenase that oxidizes the hydroxyl group at position 15 of prostaglandins to a ketone, resulting in a loss of biological activity (1). HPGD is a major enzyme for the catabolism of prostaglandins. The enzyme is a member of the short-chain alcohol dehydrogenase family of enzymes (2). HPGD is a cytosolic enzyme expressed in most tissues, with highest expression levels in placenta, lung, and kidney (3). It is inhibited by aspirin and nonsteroidal anti-inflammatory drugs (4). Defects in HPGD are a cause of hypertrophic osteoarthropathy (5).

Product Datasheets

Related Research Areas

• Additional Reduction/Oxidation (Redox) Enzymes
• Bioactive Lipids and Receptors
• Cancer Biomarkers
• Dehydrogenases/Reductases
• Eicosanoids and Regulators
• Lipid/Cholesterol Metabolism Enzymes
• Redox Enzymes
• Steroid Hormones and Bioactive Lipids