HU 308
Chemical Name: (1S,4S,5S)-4-[4-(1,1-Dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene-2-methanol
Purity: ≥98%
Biological Activity
HU 308 is a potent and selective CB2 receptor agonist (Ki values are 22.7 nM and > 10 μM for CB2 and CB1 receptors respectively, EC50 = 5.57 nM). Displays antiallodynic activity in the rat hindpaw incision model of postoperative pain. Also neuroprotective and improves motor performance in a mouse model of Huntington's Disease.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The endocannabinoid/endovanilloid N-arachidonoyl dopamine (NADA) and synthetic cannabinoid WIN55,212-2 abate the inflammatory activation of human endothelial cells.
Wilhelmsen K, Khakpour S, Tran A, Sheehan K, Schumacher M, Xu F, Hellman J
J Biol Chem, 2014;289(19):13079-100. -
Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice.
Schmitz K, Mangels N, Haussler A, Ferreiros N, Fleming I, Tegeder I
Int J Obes (Lond), 2015;40(2):366-79. -
Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages
PLoS ONE, 2016;11(9):e0155076. -
Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Palazuelos et al.
Brain, 2009;132:3152 -
Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain.
LaBuda et al.
Eur.J.Pharmacol., 2005;527:172 -
HU-308: a specific agonist for CB2, a peripheral cannabinoid receptor.
Hanus et al.
Proc.Natl.Acad.Sci.USA, 1999;96:14228
Product Datasheets
Citations for HU 308
The citations listed below are publications that use Tocris products. Selected citations for HU 308 include:
7 Citations: Showing 1 - 7
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Altered Swimming Behaviors in Zebrafish Larvae Lacking Cannabinoid Receptor 2.
Authors: Acevedo-Canabal Et al.
Cannabis Cannabinoid Res 2019;4:88
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Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Authors: Sheng Et al.
Pain Res Manag 2019;2019:1260353
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Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages
Authors: Ke Et al.
PLoS One 2016;11:e0155076
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Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist.
Authors: Presley Et al.
Brain Res 2015;3:e00159
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Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
Authors: Gianella-Borradori Et al.
Bioorg Med Chem 2015;23:241
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Experimental cannabinoid 2 receptor-mediated immune modulation in sepsis.
Authors: Sardinha Et al.
Pharmacol Res Perspect 2014;2014:978678
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Prospects for cannabinoid therapies in viral encephalitis.
Authors: Solbrig Et al.
Proc Natl Acad Sci U S A 2013;1537:273
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