HLI 373
Chemical Name: 5-[[3-Dimethylamino)propyl]amino]-3,10-dimethylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione dihydrochloride
Purity: ≥99%
Biological Activity
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Ubiquitin-dependent proteolysis of CXCL7 leads to posterior longitudinal ligament ossification
M Tsuru, A Ono, H Umeyama, M Takeuchi, K Nagata
PLoS ONE, 2018;13(5):e0196204. -
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2.
Kitagaki et al.
Mol.Cancer Ther., 2008;7:2445 -
Targeting the ubiquitin-proteasome system for cancer therapy.
Yang et al.
Cancer Sci., 2009;100:24
Product Datasheets
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