HJC 0350
Chemical Name: 2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole
Purity: ≥98%
Biological Activity
HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). Displays no effect on Epac1. Blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
Chen et al.
J.Med.Chem., 2013;56:952
Product Datasheets
Citations for HJC 0350
The citations listed below are publications that use Tocris products. Selected citations for HJC 0350 include:
2 Citations: Showing 1 - 2
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Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
Authors: Derek C Et al.
J Neurosci 2021;41:2883-2898
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The EPAC-Rap1 pathway prevents and reverses cytokine-induced retinal vascular permeability.
Authors: Cheng-Mao Et al.
J Biol Chem 2018;293:717-730
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