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Histamine dihydrochloride

Catalog #: 3545
9 Citations Datasheet
Catalog # Availability Size / Price Qty
3545/50
Histamine dihydrochloride | CAS No. 56-92-8 | Histamine H1 Receptor Agonists
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Description: Endogenous histamine receptor agonist

Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride

Product Details
Citations (9)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Histamine dihydrochloride is an endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Technical Data

M.Wt:
184.07
Formula:
C5H9N3.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at RT
CAS No:
56-92-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Cell chirality regulates intercellular junctions and endothelial permeability
    J Fan, P Ray, Y Lu, G Kaur, JJ Schwarz, LQ Wan
    Sci Adv, 2018;4(10):eaat2111.
  2. International union of pharmacology. XIII. Classification of histamine receptors.
    Hill et al.
    Pharmacol.Rev., 1997;49:253
  3. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
    Thurmond et al.
    Nat.Rev.Drug Discov., 2008;7:41
  4. Histamine and histamine intolerance.
    Maintz and Novak
    Am.J.Clin.Nutr., 2007;85:1185

Product Datasheets

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Citations for Histamine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:

9 Citations: Showing 1 - 9

  1. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility.
    Authors: David E Et al.
    Cell  2022;185:3390-3407.e18
  2. 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors.
    Authors: Vincenzo Et al.
    Mol Brain  2021;14:28
  3. G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells.
    Authors: JoAnn Et al.
    J Biol Chem  2019;294:5867-5878
  4. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
    Authors: Thomas C Et al.
    Cell  2019;179:498-513.e22
  5. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
    Authors: Hao Et al.
    Neuron  2019;102:745-761.e8
  6. Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop.
    Authors: Chen Et al.
    Cell Stem Cell  2017;21:747
  7. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  8. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression.
    Authors: Femenia Et al.
    Int J Neuropsychopharmacol  2015;18
  9. Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells.
    Authors: Melchior and Frangos
    Acta Pharmacol Sin  2012;303:C467

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