HIOC
Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-2-oxo-3-piperidinecarboxamide
Purity: ≥98%
Biological Activity
HIOC is a selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Gram-scale, chemoselective synthesis of N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]-2-oxopiperidine-3-carboxamide (HIOC)
Setterholm et al.
Tetrahedron Lett., 2015;56:3413 -
N-acetyl serotonin derivatives as potent neuroprotectants for retinas
Shen et al.
Proc.Natl.Acad.Sci.USA, 2012;109:3540
Product Datasheets
Citation for HIOC
The citations listed below are publications that use Tocris products. Selected citations for HIOC include:
1 Citation: Showing 1 - 1
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Minocycline promotes posthemorrhagic neurogenesis via M2 microglia polarization via upregulation of the TrkB/BDNF pathway in rats.
Authors: Hang Et al.
J Neurophysiol 2018;120:1307-1317
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