Home / Smoothened / Hh-Ag1.5

Hh-Ag1.5

Catalog #: 7807 Datasheet
Catalog # Availability Size / Price Qty
7807/1
7807/5
Hh-Ag1.5 | CAS No. 612542-14-0 | Smoothened
1 Image
Description: Potent and high affinity Smo receptor agonist

Chemical Name: 3-Chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Hh-Ag1.5 is a potent and high affinity Smoothened (Smo) receptor agonist (EC50 = 1 nM; Ki values are 0.5 and 2.3 nM respectively, in a [3H]SAG-1.3 and [3H]Cyclopamine binding assay). It is used in protocols for the chemical reprogramming of mouse embryonic fibroblasts into neural stem cells. Also induces differentiation of hiPSCs into skin-derived precursor cells, spinal motor neurons and spinal sensory neurons.

Technical Data

M.Wt:
526.04
Formula:
C28H26ClF2N3OS
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
612542-14-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Evidence for allosteric interactions of antagonist binding to the smoothened receptor.
    Rominger et al.
    J.Pharmacol.Exp.Ther., 2009;329:995

Product Datasheets

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Hh-Ag1.5

There are currently no reviews for this product. Be the first to review Hh-Ag1.5 and earn rewards!

Have you used Hh-Ag1.5?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.