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H 151

Catalog #: 6675
2 Citations Datasheet
Catalog # Availability Size / Price Qty
6675/10
6675/50
H 151 | CAS No. 941987-60-6 | STING Antagonists
1 Image
Description: STING antagonist

Chemical Name: N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

Technical Data

M.Wt:
279.34
Formula:
C17H17N3O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
941987-60-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Targeting STING with covalent small-molecule inhibitors.
    Haag et al.
    Nature, 2018;559:269

Product Datasheets

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Citations for H 151

The citations listed below are publications that use Tocris products. Selected citations for H 151 include:

2 Citations: Showing 1 - 2

  1. Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies.
    Authors: Kevin C Et al.
    J Exp Med  2023;220
  2. STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity.
    Authors: Ying Et al.
    Adv Sci (Weinh)  2023;10:e2203718

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