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GYKI 53655 hydrochloride

Catalog #: 2555
11 Citations Datasheet
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2555/10
2555/50
GYKI 53655 hydrochloride | CAS No. 143692-48-2 | AMPA Receptor Antagonists
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Description: Non-competitive non-NMDA iGluR antagonist

Chemical Name: 1-(4-Aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride

Purity: ≥99%

Product Details
Citations (11)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

GYKI 53655 hydrochloride is a non-competitive AMPA and kainate receptor antagonist. Analog of GYKI 52466 (Cat. No. 1454). Prolongs the survival time after MgCl2- induced global cerebral ischemia. Exhibits anticonvulsant activity. Also blocks GluK3 homomeric receptors (IC50 = 63 μM) and GluK2b(R)/GluK3 heteroreceptors (IC50 = 32 μM) at high concentrations.

Technical Data

M.Wt:
388.85
Formula:
C19H20N4O3.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
143692-48-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for GYKI 53655 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for GYKI 53655 hydrochloride include:

11 Citations: Showing 1 - 10

  1. Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.
    Authors: Lu Et al.
    Neuron  2017;96:73
  2. Ca2+-permeable AMPA receptors in mouse olfactory bulb astrocytes.
    Authors: Droste Et al.
    Sci Rep  2017;7:44817
  3. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci  2015;9:275
  4. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    J Neurosci  2015;35:13336
  5. A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity.
    Authors: Ben-Simon Et al.
    PLoS One  2015;12:396
  6. Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons.
    Authors: Falgairolle and O'Donovan
    Pharmacol Res Perspect  2015;10:e0131430
  7. Heterogeneity in expression of functional ionotropic glutamate and GABA receptors in astrocytes across brain regions: insights from the thalamus.
    Authors: Höft Et al.
    Philos Trans R Soc Lond B Biol Sci  2014;369:20130602
  8. Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell.
    Authors: Buldyrev Et al.
    J Neurophysiol  2012;107:1795
  9. Neto1 is an auxiliary subunit of native synaptic kainate receptors.
    Authors: Tang Et al.
    Cell Rep  2011;31:10009
  10. Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
    Authors: Straub Et al.
    Nat Neurosci  2011;14:866

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