Guanylin (human)
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Description: Endogenous activator of intestinal guanylyl cyclase
Purity: ≥95%
Biological Activity
Guanylin (human) is an endogenous peptide activator of intestinal guanylyl cyclase; secreted mainly by the gastrointestinal mucosa. Regulates water and electrolyte transport in intestinal and renal epithelia.Technical Data
M.Wt:
1458.65
Formula:
C58H87N15O21S4
Sequence:
PGTCEICAYAACTGC
(Modifications: Disulfide Bridges: 4-12, 7-15)
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
183200-12-6
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Guanylin: an endogenous activator of intestinal guanylate cyclase.
Currie et al.
Proc.Natl.Acad.Sci.U.S.A., 1992;89:947 -
Guanylin and related peptides.
Beltowski
J.Physiol.Pharmacol., 2001;52:351 -
Synthesis, solution structure, binding activity, and cGMP activation of human guanylin and its disulfide isomer.
Nokihara et al.
Regul.Pept., 1997;70:111
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