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Granisetron hydrochloride

Catalog #: 2903
4 Citations Datasheet
Catalog # Availability Size / Price Qty
2903/10
2903/50
Granisetron hydrochloride | CAS No. 107007-99-8 | 5-HT3 Receptor Antagonists
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Description: 5-HT3 antagonist
Alternative Names: BRL 43694

Chemical Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride

Purity: ≥99%

Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Granisetron hydrochloride is a 5-HT3 receptor antagonist that possesses potent antiemetic activity.

Technical Data

M.Wt:
348.87
Formula:
C18H24N4O.HCl
Solubility:
Soluble to 100 mM in water and to 10 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
107007-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Modulation of proteoglycan receptor PTP? enhances MMP-2 activity to promote recovery from multiple sclerosis
    F Luo, AP Tran, L Xin, C Sanapala, BT Lang, J Silver, Y Yang
    Nat Commun, 2018;9(1):4126.
  2. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron).
    Sanger and Nelson
    Eur.J.Pharmacol., 1989;159:113
  3. Granisetron. A review of its pharmacological properties and therapeutic use as an antiemetic.
    Plosker and Goa
    Drugs, 1991;42:805
  4. Anti-emetic effect of ondans. and granis. after exposure to mixed neutron and gamma irradiation.
    Martin et al.
    Rad.Res., 1998;149:631

Product Datasheets

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Citations for Granisetron hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Granisetron hydrochloride include:

4 Citations: Showing 1 - 4

  1. Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms.
    Authors: Otvos Et al.
    Neuropharmacology  2015;7:2336
  2. Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  3. Unique ionotropic receptors for D-aspartate are a target for serotonin-induced synaptic plasticity in Aplysia californica.
    Authors: Carlson and Fieber
    Comp Biochem Physiol C Toxicol Pharmacol  2012;155:151
  4. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
    Authors: Murray Et al.
    J Neurophysiol  2011;106:925

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