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Golgicide A

Catalog #: 3584
5 Citations Datasheet
Catalog # Availability Size / Price Qty
3584/10
3584/50
Golgicide A | CAS No. 1139889-93-2 | ARF GTPase Inhibitors
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Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF

Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data

M.Wt:
284.3
Formula:
C17H14F2N2
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
1139889-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function.
    Saenz et al.
    Nature Chem.Biol., 2008;5:157

Product Datasheets

Citations for Golgicide A

The citations listed below are publications that use Tocris products. Selected citations for Golgicide A include:

5 Citations: Showing 1 - 5

  1. Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade.
    Authors: Guido Et al.
    Cell Death Differ  2021;28:1733-1752
  2. Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking.
    Authors: Marta Et al.
    Glia  2019;67:404-417
  3. Recruitment of LC3 to damaged Golgi apparatus.
    Authors: Gomes-da-Silva Et al.
    Cell Death Differ  2019;26:1467
  4. VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells.
    Authors: Ryan T Et al.
    Cell  2019;178:748-761.e17
  5. GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells.
    Authors: Krokowski
    Cell Rep  2017;21(10):2895

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